Moutan Cortex Radicis Extract Fraction for Liver Disease Treatment
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Solution Overview
Problem
Current treatments for liver diseases, including hepatitis and cirrhosis, face challenges due to limited hepatic protection and side effects, and there is a need for natural substance-derived therapeutic agents with established effective doses and pharmacological effects.
Innovation Solution
A pharmaceutical and health functional food composition incorporating an ethyl acetate fraction of Moutan Cortex Radicis extract, which is obtained through solvent extraction and fractionation, is used to inhibit liver injury indicators such as ALT concentration, TLR4 protein expression, and lipid peroxidation, offering liver protection with minimal toxicity and side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional drugs (hepatocyte regeneration promoters, antiviral agents, immunosuppressants, fibrosis inhibitors) are used for liver disease treatment, then specific therapeutic effects are achieved, but side effects and limited hepatic protection occur
Solution Approach 1:
The patent extracts and isolates specific active components from Moutan Cortex Radicis, focusing on paeonol and related compounds. This extraction principle allows the invention to utilize only the beneficial hepatoprotective components while excluding potentially harmful substances, thereby achieving therapeutic effects with reduced side effects
Solution Approach 2:
The patent optimizes the chemical structure and concentration parameters of paeonol derivatives to enhance hepatoprotective activity. By modifying molecular parameters such as substitution patterns and purity levels, the invention achieves improved therapeutic efficacy while maintaining safety
2Object-affected harmful factors
If natural substances are used as therapeutic agents for liver disease, then biocompatibility and minimal side effects are achieved, but lack of basic research on effective dose and exact pharmacological effect makes difficult their use as therapeutic agents
Solution Approach 1:
The patent establishes feedback mechanisms through in vitro and in vivo experiments to determine optimal dosing regimens and pharmacological effects of paeonol. By systematically testing various concentrations and administration protocols, the invention generates the necessary pharmacological data to bridge the gap between natural substance safety and therapeutic effectiveness
Solution Approach 2:
The patent conducts preliminary pharmacological studies and toxicity assessments before clinical application. By performing advance research on effective doses and pharmacological mechanisms, the invention prepares comprehensive data packages that enable subsequent therapeutic use of the natural substance
3Reliability
If Moutan Cortex Radicis extract is used to inhibit liver injury indicators, then liver protective effect is achieved, but need for fractionation and purification increases complexity of preparation
Solution Approach 1:
The patent divides the complex Moutan Cortex Radicis extract into distinct fractions based on solubility and chemical properties. By segmenting the extract into ethyl acetate, butanol, and water fractions, the invention isolates the hepatoprotective components from non-essential substances, simplifying the active ingredient profile while maintaining efficacy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces blood ALT concentration, inhibits TLR4 and IL-1β protein expression, and prevents lipid peroxidation in the liver, demonstrating excellent liver protective efficacy with reduced side effects, making it suitable for long-term use in preventing or treating liver diseases.
Implementation Method 1
which is obtained through solvent extraction and fractionation
Implementation Method 2
which is obtained through solvent extraction and fractionation
Data Source
AI summary
The present invention relates to a composition containing a fraction of a Mouton Radicis Cortex extract, which can be advantageously used in the prevention or treatment of liver diseases. In the present invention, it was specifically verified that the use of the composition can effectively reduce the blood ALT concentration, inhibit the increase of TLR4 or IL-1β protein expression in the liver, and also inhibit the lipid peroxidation in the liver, and thus, it is expected that the composition can attain target therapy through a more fundamental approach in the prevention or treatment of liver diseases.