Chromatograph Mass Spectrometer Data Acquisition Consistency
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Solution Overview
Problem
Chromatograph mass spectrometers face variations in data acquisition intervals due to changes in the number of MSn-1 and MSn analyses depending on the analysis period, leading to inconsistent chromatogram data acquisition.
Innovation Solution
A chromatograph mass spectrometer with an MSn-1 analysis setter, analysis period divider, MSn analysis setter, MSn analysis execution time allotter, and analysis executer, which allows for a common data acquisition interval by dividing the analysis period into segments and allocating time for MSn analyses based on the number of MSn-1 analyses, ensuring consistent data acquisition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If the number of MSn-1 and MSn analyses is changed depending on the analysis period, then the analysis flexibility and adaptability are improved, but the data acquisition interval becomes inconsistent
Solution Approach 1:
The analysis period is divided into multiple analysis period segments, where each segment contains a fixed number of MSn-1 analyses. This segmentation allows the system to maintain consistent data acquisition intervals within each segment while still providing flexibility across different analysis periods by adjusting the number and configuration of segments.
Solution Approach 2:
The system dynamically adjusts the number of MSn analyses performed within each analysis period segment based on the number of MSn-1 analyses completed. This dynamic adjustment mechanism ensures that the data acquisition interval remains consistent while adapting to varying analytical requirements across different time windows.
2Measurement precision
If the number of MSn analyses is increased to improve identification accuracy, then the analysis completeness is improved, but the data acquisition interval varies
Solution Approach 1:
The system implements periodic MSn analyses within each analysis period segment, where the number of repetitions is determined by the loop time and the number of MSn-1 analyses. This periodic structure ensures that data is acquired at regular intervals, maintaining consistency in the data acquisition process while still allowing multiple analyses for improved identification accuracy.
3Productivity
If the loop time is extended to perform more MSn analyses, then the analysis depth is improved, but the data acquisition frequency decreases
Solution Approach 1:
Instead of extending a single loop time, the system segments the analysis into multiple analysis period segments with fixed loop times. Each segment contains a predetermined number of MSn-1 analyses, allowing the system to maintain high data acquisition frequency within each segment while achieving deep analysis across multiple segments.
Solution Approach 2:
The system maintains continuous data acquisition across analysis period segments by ensuring that each segment completes its fixed number of analyses within the loop time. This continuity allows the system to perform multiple MSn analyses without creating gaps in data acquisition, thereby maintaining both analysis depth and data acquisition frequency.
Data Source
AI summary
A chromatograph mass spectrometer including: an MSn-1 analysis setter for setting an analysis execution period for performing an MSn-1 analysis, an execution time for the analysis and a loop time; an analysis period divider for dividing the analysis period into segments according to a change in number or analysis condition of MSn-1 analyses to be performed within the same time window; an MSn analysis setter for performing MSn-1 analysis to obtain mass spectrum data and for scheduling MSn analysis, an ion corresponding to a peak satisfying a set condition being designated as a precursor ion; an MSn analysis execution time allotter for allotting, in each segment, a time period for execution of the MSn analysis, the time period being calculated by subtracting an event execution time from the loop time; and an analysis executer for repeatedly performing MSn-1 analysis and MSn analysis in each segment.