Multi-Length Microneedle Assembly for Deeper Transdermal Delivery
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Solution Overview
Problem
Minimally invasive transdermal drug delivery systems face limitations in diffusion range and absorption efficiency due to uniform needle lengths, resulting in poor user experience.
Innovation Solution
A preparation delivery assembly with at least two needles of different lengths, each with a hollow structure, and a temperature control circuit to maintain preparation in an injectable state, along with flexible substrates and channels for uniform delivery and air regulation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If uniform needle lengths are used in the preparation delivery assembly, then the device structure is simple and easy to manufacture, but the diffusion range of the preparation is limited and absorption efficiency is poor
Solution Approach 1:
The needle array is segmented into multiple length groups (first length, second length, third length) with different penetration depths. This segmentation allows the preparation to be delivered to multiple dermal layers simultaneously, expanding the diffusion range and improving absorption efficiency while maintaining a manageable device structure through systematic organization of the segmented needles.
Solution Approach 2:
Different regions of the needle array are assigned different needle lengths to create local quality variations. The first length needles target the first dermal layer, second length needles target the second dermal layer, and third length needles target the third dermal layer. This local differentiation optimizes preparation delivery to specific depths, enhancing overall absorption efficiency without requiring complete redesign of the entire device.
2Productivity
If multiple needles of different lengths are used to expand diffusion range, then preparation absorption efficiency improves, but the device complexity increases
Solution Approach 1:
Needles of different lengths are merged into a single integrated needle array structure that is fixed to the second substrate. This merging approach consolidates multiple functional elements (needles of different lengths, substrate attachment, channel connections) into one unified device, improving preparation absorption efficiency while controlling device complexity through integration rather than separate components.
Solution Approach 2:
The needle array is designed with multi-functionality by incorporating needles of at least three different lengths that can simultaneously target multiple dermal layers. This universal design allows a single device to perform multiple delivery functions (first dermal layer delivery, second dermal layer delivery, third dermal layer delivery) without requiring separate devices for each layer, thereby improving absorption efficiency while avoiding proportional increases in device complexity.
Data Source
AI summary
A preparation delivery assembly includes: a first substrate, a second substrate, and at least two needles of different lengths. Two side walls are provided between the first and second substrates to define a first chamber. At least one first channel that is in communication with the first chamber is provided in the second substrate in a direction perpendicular to the second substrate. And the needles are arranged on a surface of the second substrate, and each needle is in communication with the first chamber to deliver the preparation. A third channel is provided in the first substrate in a direction perpendicular to the first substrate, and one end of the third channel is in communication with the first chamber so as to guide the preparation introduced from the other end of the third channel into the first chamber.