Multi-layer Biomaterial for Tissue Regeneration
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Solution Overview
Problem
Existing biomaterial scaffolds for tissue regeneration and wound healing often lead to long-term graft failure due to implant contracture, rupture, and fibrosis, resulting in delayed wound healing and potential morbidity.
Innovation Solution
A multi-layer biomaterial composition comprising a porous biomaterial matrix layer and an impermeable biomaterial layer, where the layers can be made from materials like silk fibroin, PGA, or collagen, with the impermeable layer preventing fluid and cellular movement, and the porous layer allowing for tissue regeneration and cell migration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a porous biomaterial scaffold is used for tissue regeneration, then cell migration and tissue growth are promoted, but the scaffold lacks mechanical strength and leads to graft rupture
Solution Approach 1:
The patent employs a composite structure consisting of a porous biomaterial scaffold layer combined with a dense impermeable barrier layer. The porous scaffold (made from materials like collagen, gelatin, or synthetic polymers) provides tissue regeneration capability by allowing cell infiltration and nutrient transport, while the dense barrier layer contributes mechanical strength and prevents scaffold rupture. This composite configuration resolves the contradiction by integrating materials with complementary properties.
Solution Approach 2:
The invention divides the graft structure into functionally distinct segments: a porous scaffold portion for tissue regeneration and a dense barrier portion for mechanical support. This segmentation allows each layer to optimize its specific function without compromising the other, enabling the porous region to promote cell growth while the dense region provides structural integrity and prevents rupture.
2Reliability
If a dense impermeable barrier is used to seal wounds, then fluid leakage is prevented, but tissue regeneration and cell migration are inhibited
Solution Approach 1:
The graft is segmented into two distinct functional layers: a dense impermeable barrier layer that provides reliable wound sealing and fluid containment, and a porous scaffold layer that enables tissue regeneration and cell migration. This segmentation allows the dense barrier to fulfill its sealing function without inhibiting regenerative processes, as these occur in the adjacent porous region.
Solution Approach 2:
The invention combines materials with contrasting permeability properties into a composite structure. The dense barrier portion uses impermeable materials to ensure reliable sealing, while the porous scaffold portion uses permeable materials to support tissue regeneration. This composite approach resolves the contradiction by spatially separating conflicting functional requirements.
3Ease of manufacture
If a uniform biomaterial structure is used, then manufacturing is simplified, but the material cannot simultaneously provide both scaffolding and sealing functions
Solution Approach 1:
The manufacturing process is segmented into distinct steps for creating the porous scaffold layer and the dense barrier layer, each optimized for its specific function. This segmentation allows each layer to be manufactured using appropriate techniques while maintaining overall process simplicity, and enables the final composite structure to achieve dual functionality that neither layer could provide alone.
Solution Approach 2:
The invention uses composite material construction to achieve dual functionality (scaffolding and sealing) while maintaining manufacturing feasibility. By combining separately manufacturable layers with distinct properties into a single composite graft, the invention achieves versatility without excessive manufacturing complexity.
4Device complexity
If existing single-layer scaffolds are used, then the structure is simple, but long-term graft failure occurs due to contracture and fibrosis
Solution Approach 1:
The graft structure is segmented into functionally distinct layers that address different failure mechanisms: the porous scaffold layer supports tissue regeneration while the dense barrier layer prevents contracture and reduces fibrosis. This segmentation creates a more reliable long-term outcome compared to single-layer scaffolds, while maintaining reasonable structural simplicity through the use of just two layers.
Solution Approach 2:
The invention employs a composite two-layer structure that combines materials and architectures suited for different functional requirements. This composite approach improves long-term reliability by preventing contracture and fibrosis through the dense barrier layer, while the porous scaffold layer continues to support tissue regeneration, thereby addressing the limitations of single-layer scaffolds.
Data Source
AI summary
The technology described herein is directed to compositions comprising at least a first porous biomaterial layer and a second impermeable biomaterial layer and methods relating thereto. In some embodiments, the compositions and methods described herein relate to wound healing, e.g. repair of wounds and/or tissue defects.