Compositions and methods containing N-acetylcystein and nicotinamide riboside for prevention and treatment of neurological diseases and conditions
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Solution Overview
Problem
There is an urgent need to address neurological diseases and conditions associated with oxidative stress, mitochondrial dysfunction, and brain energy deficits, particularly in aging populations, to prevent or delay cognitive decline and neurodegenerative diseases.
Innovation Solution
Compositions comprising a combination of N-acetylcysteine or its functional derivatives and nicotinamide riboside or NAD+ precursors are administered orally or enterally to improve brain function, enhance neurological recovery, and treat neurological conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional single-component antioxidants or NAD+ precursors are used, then some protective effect against oxidative stress is achieved, but the effect is insufficient to fully prevent cognitive decline and mitochondrial dysfunction
Solution Approach 1:
The patent combines N-acetylcysteine (an antioxidant that increases glutathione levels) with nicotinamide riboside (an NAD+ precursor) into a single compositional formulation. This merging of two distinct protective mechanisms—oxidative stress reduction and mitochondrial energy production enhancement—creates a synergistic effect that overcomes the limitations of single-component treatments, thereby improving both reliability of protection and productivity of cognitive function maintenance
2Reliability
If high doses of individual antioxidants or NAD+ precursors are administered, then stronger protective effects are achieved, but side effects and toxicity increase
Solution Approach 1:
The patent optimizes the dosage parameters of both N-acetylcysteine and nicotinamide riboside within specific ranges (NAC: 6-6000 mg/day, NR: 0.001-1000 mg/day) to achieve therapeutic effects while minimizing toxicity. By carefully controlling these parameters and using them in combination at moderate doses rather than high single doses, the formulation achieves reliable protection against oxidative stress without the harmful side effects associated with high-dose monotherapies
3Reliability
If multiple separate treatments are administered to address oxidative stress and mitochondrial dysfunction, then comprehensive protection is achieved, but treatment complexity and compliance difficulty increase
Solution Approach 1:
The patent merges two separate therapeutic agents (N-acetylcysteine and nicotinamide riboside) into a single compositional formulation that can be administered together. This consolidation provides comprehensive protection against both oxidative stress and mitochondrial dysfunction while simplifying the treatment regimen from multiple separate administrations to one unified supplement, thereby reducing complexity and improving patient compliance
4Reliability
If early intervention to prevent cognitive decline is implemented, then long-term brain health is improved, but the duration of treatment required increases
Solution Approach 1:
The patent employs a continuous supplementation regimen with the NAC+NR composition that simultaneously addresses multiple age-related neurological risks (oxidative stress, mitochondrial dysfunction, cognitive decline). By providing continuous dual protection through this unified formulation, the treatment achieves long-term brain health benefits more efficiently than intermittent or single-mechanism approaches, effectively managing the treatment duration while maintaining reliable protection
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compositions effectively maintain or improve brain function, enhance neurological recovery, and prevent or treat neurological diseases by influencing oxidative stress and mitochondrial pathways, thereby improving cognitive function and overall brain health.
Implementation Method 1
N-acetylcysteine (NAC) or functional derivatives, and nicotinamide riboside (NR) or NAD+ precursors can increase intracellular levels of glutathione (GSH) and/or NAD+ in cells and tissues
Implementation Method 2
N-acetylcysteine (NAC) or functional derivatives, and nicotinamide riboside (NR) or NAD+ precursors can increase intracellular levels of glutathione (GSH) and/or NAD+ in cells and tissues
Implementation Method 3
The compositions effectively maintain or improve brain function, enhance neurological recovery, and prevent or treat neurological diseases by influencing oxidative stress and mitochondrial pathways
Data Source
AI summary
The present invention provides compositions containing at least one N-acetyl cysteine and at least one nicotinamide riboside for use in methods of prevention and/or treatment of neurological disease and/or conditions. In one embodiment of the invention, said compositions of the invention maintain or improve brain function, in particular brain energy deficits. In another embodiment of the invention, compositions of the invention improve neurological recovery and regeneration after injury or surgery. In another embodiment of the invention compositions of the invention may be used in methods to prevent and/or treat neurological diseases and/or conditions and/or recovery after injury or surgery.