Nano-sized Kimchi Lactic Acid Bacteria for Intestinal Absorption
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Solution Overview
Problem
Conventional kimchi lactic acid bacteria strains have limited absorption in the intestine and reduced viability when used as food, leading to diminished effectiveness in improving the intestinal environment and treating colorectal diseases.
Innovation Solution
Development of nano-sized Lactobacillus plantarum strain isolated from kimchi, which is used as a food additive or in pharmaceutical compositions to enhance intestinal absorption and treat colorectal diseases, with the strain being processed into uniform particles for improved bioavailability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional kimchi lactic acid bacteria are used as food, then they can be taken orally, but they are drastically decreased in cell counts in intestinal environment and not absorbed in intestine
Solution Approach 1:
The patent applies parameter changes by transforming the bacteria into nano-sized particles (10-100 nm diameter), which fundamentally alters their physical state and enables them to survive the intestinal environment and be absorbed through the intestinal wall, thereby resolving the contradiction between oral administration and intestinal survival
Solution Approach 2:
The invention transitions the bacteria from macroscopic cellular form to nanoscopic particles, representing a dimensional change that enables new functions including intestinal absorption and resistance to digestive conditions, thus maintaining reliability while improving productivity in terms of cell count survival
2Quantity of substance
If strains are grown in predetermined volume of culture solution, then they can be produced, but the daily intake is limited
Solution Approach 1:
By changing the physical state of the bacteria to nano-sized particles, the patent enables much higher concentration and density of bacterial cells in the same volume of culture solution, thereby increasing the quantity of substance (daily intake) without proportionally increasing the volume of culture solution
3Reliability
If lactic acid bacteria are used to inhabit intestine and prevent abnormal fermentation, then they function as digestive, but they are drastically decreased in cell counts and not absorbed
Solution Approach 1:
The transformation into nano-sized particles fundamentally changes the bacteria's ability to interact with the intestinal environment, enabling them to resist digestive conditions, be absorbed through the intestinal wall, and reach the intestinal habitat, thus resolving both the reliability of preventing abnormal fermentation and the ease of operation regarding intestinal absorption
Data Source
AI summary
A nano-sized Lactobacillus plantarum (L. plantarum) nF1 strain isolated from kimchi and which has a particle size distribution of 0.5 to 1.0 μm. Pharmaceutical compositions and functional food compositions comprising the nano-sized L. plantarum nF1 strain may be used to prevent and treat colorectal diseases including colitis and colorectal cancer.