Nanovesicle Plasma Coating for Surface Charge Neutralization

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Solution Overview

Problem

Nanovesicles face challenges in cell penetration due to their negative surface charge, leading to decreased therapeutic efficacy in drug delivery, as the negative charge causes electrostatic repulsion with cell membranes, and existing modifications have not effectively addressed this issue.

Innovation Solution

A plasma coating method using a plasma jet device applies neutral charge plasma to nanovesicles, converting their surface charge from negative to neutral, enhancing intracellular penetration and drug delivery efficiency by dissolving them in a phosphate buffered saline solution and applying specific voltage and gas flow conditions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If nanovesicles are used for drug delivery, then drug delivery capability is improved, but cell penetration is reduced due to negative surface charge causing electrostatic repulsion

Engineering Contradiction:

Improvedrug delivery capabilityVSAvoidelectrostatic repulsion

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies plasma treatment to change the surface charge parameter of nanovesicles from negative to neutral or positive. By controlling plasma treatment conditions (gas type, power, duration), the surface charge density is modified, transforming the electrostatic interaction from repulsive to attractive or neutral, thereby improving cell penetration while preserving drug delivery capability

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent replaces conventional chemical modification methods with plasma treatment. Instead of using chemical reagents to modify surface charge, plasma provides a physical treatment method that directly alters surface properties through ion bombardment and radical reactions, achieving charge neutralization without introducing chemical contaminants

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Reliability

If surface charge of nanovesicles is modified to improve cell penetration, then therapeutic efficacy is improved, but existing methods have not provided effective solutions

Engineering Contradiction:

Improvetherapeutic efficacyVSAvoidsurface charge modification effectiveness

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent systematically optimizes plasma treatment parameters including gas flow rate (5-50 sccm), power (50-500 W), and treatment duration (1-30 minutes) to achieve effective surface charge modification. By establishing parameter ranges that consistently produce neutral or positive surface charge, the method provides a reliable and reproducible approach to improving therapeutic efficacy

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses plasma as an intermediary medium to transfer charge to the nanovesicle surface. The plasma, generated from inert gases like nitrogen or argon, serves as a controllable source of ions and radicals that can be deposited on the nanovesicle surface, providing a versatile and tunable method for surface charge modification

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The plasma coating method effectively neutralizes the surface charge of nanovesicles, improving their ability to penetrate cells and enhance drug delivery efficiency, as demonstrated by increased positive ion attachment and improved intracellular drug delivery characteristics.

Implementation Method 1

applying a preset voltage to the plasma jet device and performing plasma coating on the surface of the nanovesicles under preset gas flow conditions

Methodology Applied

Scientific EffectPlasma generation: Plasma

Implementation Method 2

the negative charge causes an unbalanced electrostatic interaction with the cell membrane, and the resulting electron repulsion inhibits cell penetration

Methodology Applied

Scientific EffectElectrostatic interaction: Electrostatics

Implementation Method 3

the charge on the surface of the nanovesicles may be converted from negative to neutral

Methodology Applied

Scientific EffectCharge neutralization: Electrostatic Induction

Data Source

PatentUS20250009661A1Plasma coating method of nanovesicle surface and plasma jet device for plasma coating of nanovesicle surface

Publication Date: 2025.01.09 RES & BUSINESS FOUND SUNGKYUNKWAN UNIV

AI summary

An embodiment of the disclosure provides a plasma coating method of a nanovesicle surface and a plasma jet device for plasma coating of a nanovesicle surface. The plasma coating method of a nanovesicle surface according to an embodiment of the disclosure may be provided as a simple method for changing the surface charge of a nanovesicle from negative to neutral by utilizing the characteristic that when a neutral object meets a negatively charged object, electrons of the neutral object repel electrons of the negatively charged object and the negatively charged object becomes positively charged.