Nasal Solution Coating Agents for Mucosal Adhesion
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Solution Overview
Problem
Existing nasal solutions fail to effectively line mucous membranes, limit bacterial and viral adhesion, and provide sustained coverage and acidity, leading to limited action in preventing and treating upper respiratory tract conditions.
Innovation Solution
A liquid composition comprising a mucous membrane lining agent (such as maltitol syrup), a humectant (like glycerin), and a pH adjuster (trisodium citrate dihydrate and citric acid) that maintains a pH between 3.3 and 4, ensuring stable viscosity and coverage of nasal cavities and the nasopharynx.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If existing nasal solutions are used, then they can cleanse the oropharynx and reduce pathogenic bacterial populations, but they do not coat the mucous membranes and their action is limited in duration
Solution Approach 1:
The patent changes the chemical composition parameters by incorporating specific coating agents (chitosan, gelatin, or albumin) in optimized concentrations (0.1-1% w/v) combined with humectants and pH adjusters, transforming the solution from a simple cleansing agent to a sustained-coating formulation that adheres to mucous membranes for extended periods
Solution Approach 2:
The patent creates a composite nasal solution combining multiple functional components: coating agents (chitosan/gelatin/albumin), humectants (glycerin, propylene glycol, or honey), and pH adjusters (citric acid, lactic acid, or acetic acid), where each component contributes specific properties that together achieve both coating and prolonged duration of action
2Adaptability or versatility
If existing nasal solutions are used, then they can treat bacterial infections, but they do not limit the penetration of viruses
Solution Approach 1:
The patent designs a multi-functional nasal solution where the coating agents form a physical barrier against both bacteria and viruses, while the acidic pH (3.3-4.0) provides broad-spectrum antimicrobial activity, and humectants maintain mucosal health, enabling the single formulation to address multiple types of respiratory infections simultaneously
3Object-affected harmful factors
If the pH is lowered between 3.3 and 4, then the effect on bacteria and viruses is potentiated, but the tolerance of mucous membranes may be reduced
Solution Approach 1:
The patent introduces coating agents (chitosan, gelatin, or albumin) as intermediary substances that form a protective layer between the acidic pH environment and the mucous membranes, allowing the beneficial antimicrobial effects of low pH to be maintained while the coating agents buffer and distribute the acidity to prevent direct irritation to sensitive tissue
Solution Approach 2:
The patent optimizes the pH parameter to a specific range (3.3-4.0) that balances antimicrobial effectiveness with tissue tolerance, and combines it with controlled concentrations of coating agents (0.1-1%) and humectants that further modulate the interaction between acidity and mucosal tissue
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively lines mucous membranes, reduces bacterial and viral adhesion, and maintains its action over time, providing prolonged prevention and treatment of upper respiratory tract conditions with enhanced tolerance and biocompatibility.
Implementation Method 1
The nasal solution according to the present invention coats the nasal cavities and the nasopharynx. This limits the adhesion of bacteria and/or the passage of viruses.
Implementation Method 2
A humectant is any substance that tends to absorb moisture from the air, either through absorption or adsorption. Generally speaking, a humectant is able to retain water and maintain hydration.
Implementation Method 3
The pH adjuster used in the present invention is a conjugate acid/base pair, providing the solution with buffering capacity. This is chosen to maintain the solution's pH between 3.3 and 4, preferably between 3.5 and 3.7, in a durable and stable manner over time.
Data Source
AI summary
The invention relates to a liquid composition comprising at least one mucosa-lining agent, at least one humectant, and at least one pH adjuster. The invention also relates to the use of said composition as a nasal solution in the prevention and treatment of winter illnesses, in particular upper respiratory tract conditions.