Nested Biodegradable Graft for Kinking Resistance
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Solution Overview
Problem
Graft materials with tubular structures often deform, leading to lumen occlusion, particularly in muscle tissues, which impedes tissue regeneration and revascularization by blocking the space needed for cell migration and fluid flow.
Innovation Solution
A revascularization graft material comprising an outer tube and an inner tube, both formed by knitting twisted biodegradable yarns, with the inner tube having a smaller outer diameter than the outer tube's lumen, enhancing kinking resistance and maintaining lumen space, and incorporating voids for fluid and cell movement, along with growth factors and vascular cells for tissue regeneration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If a single tubular graft material is used, then the structure is simple and easy to manufacture, but the kinking resistance is insufficient and lumen occlusion occurs
Solution Approach 1:
The patent employs a nested tubular structure where an inner tube is placed within an outer tube, both formed from knitted twisted yarns. This nested configuration provides the outer tube with structural support while allowing the inner tube to maintain lumen patency, thereby improving kinking resistance without significantly complicating the manufacturing process.
Solution Approach 2:
The graft material uses composite construction by combining two different tubular structures (inner and outer tubes) made from knitted twisted yarns. This composite approach leverages the complementary properties of both tubes to achieve superior mechanical strength and kinking resistance while maintaining manufacturability through established knitting techniques.
2Reliability
If the graft material is embedded in muscle tissue, then revascularization can be achieved, but deformation and lumen occlusion occur
Solution Approach 1:
The nested tubular structure with the inner tube providing internal support counteracts the deformation tendency when embedded in muscle tissue. The outer tube maintains structural integrity while the inner tube prevents lumen collapse, ensuring both structural stability and revascularization capability in dynamic muscle environments.
Solution Approach 2:
The patent utilizes the biodegradable property of the yarns to enable controlled parameter changes over time. The gradual decomposition and absorption of the graft material allows for dynamic adaptation to tissue regeneration while maintaining structural stability during the critical early stages, preventing deformation and lumen occlusion.
3Productivity
If the lumen is occluded due to deformation, then tissue regeneration is impeded, but maintaining lumen space requires complex structural support
Solution Approach 1:
The nested configuration provides efficient structural support with minimal complexity. The inner tube serves as a straightforward internal scaffold that maintains lumen space without requiring complex external reinforcement structures, thereby facilitating tissue regeneration while keeping the overall device design relatively simple.
Solution Approach 2:
The knitted twisted yarn structure inherently provides a porous architecture that maintains lumen patency while allowing cell infiltration and tissue regeneration. This porous structure eliminates the need for additional complex support mechanisms to prevent lumen occlusion, as the knit pattern itself provides both structural integrity and regenerative functionality.
Data Source
AI summary
Provided is a graft material capable of securing a sufficient space for regenerated tissue in the implantation site, and thereby promoting the regeneration of a blood vessel. Specifically, the present invention provides a revascularization graft material including an outer tube and an inner tube each being formed by knitting twisted yarns of biodegradable single yarns into a hollow tubular structure, wherein there is provided, in the lumen of the outer tube, at least one inner tube having an outer diameter smaller than the lumen diameter of the outer tube. The inner tube functions as a core material for the outer tube, and accordingly the revascularization graft material is excellent in kinking resistance, and the occlusion of the lumen hardly occurs.