Olive Phytocomplex Concentrate for Anti-Angiogenic Therapy

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current methods for preventing and treating pathological angiogenesis and inflammation, particularly in tumors, are inadequate, and there is a need to utilize waste products from olive oil production effectively, as they are rich in polyphenolic compounds with medical and pharmaceutical potential.

Innovation Solution

A concentrate is derived from olive vegetation water and pomace using microfiltration and reverse osmosis, enriched with hydroxytyrosol and 3,4-DHPA-EDA, which can be used in beverages or oral formulations to inhibit angiogenesis and inflammation, addressing the inefficiencies in existing treatments by improving drug delivery to tumors and treating non-tumor pathologies.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional anti-angiogenic treatments are used, then tumor blood vessel formation is inhibited, but drug delivery to tumor site is compromised due to irregular vessel structure

Engineering Contradiction:

Improveanti-angiogenic effectVSAvoiddrug delivery precision

Core Design Contradiction:

ReliabilityVSManufacturing precision

Solution Approach 1:

The invention changes the chemical parameters of the treatment by using a specific phytocomplex composition with defined ratios of hydroxytyrosol (5-20 μM), 3,4-DHPA-EDA (5-20 μM), and oleuropein (10-50 μM) instead of conventional single-agent anti-angiogenic drugs. This compositional parameter change enables effective anti-angiogenic activity while improving endothelial cell viability and maintaining better drug delivery characteristics

Inventive Principle:

Principle #35Parameter changes

2Object-affected harmful factors

If vegetation water and pomace are disposed of as waste, then environmental pollution is reduced, but valuable polyphenolic compounds are lost

Engineering Contradiction:

Improveenvironmental pollutionVSAvoidpolyphenolic compounds

Core Design Contradiction:

Object-affected harmful factorsVSLoss of substance

Solution Approach 1:

The invention converts the harmful waste product (vegetation water and pomace) into a beneficial therapeutic agent by extracting and concentrating the polyphenolic compounds. The waste material is processed through extraction, filtration, and concentration to produce a phytocomplex that treats angiogenesis and inflammation, thereby eliminating pollution while recovering valuable substances

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The invention implements a recovery process where vegetation water and pomace are subjected to extraction using solvents like ethanol or water, followed by filtration and concentration. This process recovers the polyphenolic compounds (hydroxytyrosol, 3,4-DHPA-EDA, oleuropein) from what would otherwise be discarded waste, achieving both environmental protection and substance recovery

Inventive Principle:

Principle #34Discarding and recovering

3Measurement precision

If single polyphenolic compounds are used, then specific anti-angiogenic activity is achieved, but overall therapeutic effectiveness is limited

Engineering Contradiction:

Improveanti-angiogenic activityVSAvoidtherapeutic effectiveness

Core Design Contradiction:

Measurement precisionVSReliability

Solution Approach 1:

The invention uses a composite phytocomplex containing multiple polyphenolic compounds (hydroxytyrosol, 3,4-DHPA-EDA, and oleuropein) in specific concentrations rather than a single compound. This composite approach synergistically enhances anti-angiogenic effectiveness, improves endothelial cell viability, and provides broader therapeutic benefits including anti-inflammatory and antioxidant activities

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The concentrate effectively prevents the formation of tumor blood vessels, enhances drug delivery, and treats various inflammatory conditions, demonstrating improved anti-angiogenic and anti-inflammatory effects compared to using hydroxytyrosol alone, with a potential to reduce environmental impact by repurposing waste products.

Implementation Method 1

microfiltering a sample of the olive vegetation water and/or olive pomace so as to obtain a concentrate and a permeate of microfiltration

Methodology Applied

Scientific EffectMicrofiltration: Filter (physical)

Implementation Method 2

concentrating by reverse osmosis the microfiltration permeate of step (i)

Methodology Applied

Scientific EffectReverse osmosis: Reverse Osmosis

Data Source

PatentEP3062806B1Liquid phytocomplexes from olive for Anti-inflammatory use

Publication Date: 2019.08.28 FATTORIA LA VIALLA DI GIANNI ANTONIO E BANDINO LO FRANCO SOC AGRI SEMPLICE

Figure 1A~1D
Figure 2A~2D
Figure 3A~3D

AI summary

The present invention relates to a phytocomplex or natural concentrate rich in polyphenolic compounds, such as hydroxytyrosol and 3,4-DHPA- EDA, derived from the vegetation waters of oil-bearing olives or from olive pomace resulting from the olive milling process for use in the treatment and prevention of angiogenesis and inflammation. In particular, the angiogenesis and inflammation to which reference is made is pathologic angiogenesis and inflammation, for example that which sustains the development and spread of a tumor or angiogenesis and inflammation tied to non-tumor pathologies. The present invention further relates to a beverage comprising the polyphenol concentrate and the use thereof in the treatment and prevention of angiogenesis and inflammation.