Catheter-Based Local Organ Perfusion Isolation for Targeted Therapy
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Solution Overview
Problem
Current therapy administration techniques face inefficiencies and systemic side effects due to dilution and convective transport, limiting the effectiveness of localized treatments for severe conditions like solid tumors and ischemic injuries, and conventional cooling methods cause undesired systemic effects.
Innovation Solution
A catheter-based system for localized therapy delivery and circulatory isolation, using venous access and drainage lines with occlusion devices to compartmentalize organ circulation from the systemic circulation, allowing for localized therapy delivery and isolation, with optional blood conditioning to minimize systemic impact.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If systemic pathways are used for therapy administration, then ease of accessibility is improved, but therapy effectiveness is worsened due to dilution and systemic side effects
Solution Approach 1:
The patent segments the circulatory system into isolated compartments using occlusion devices (balloons) to separate the target organ's blood flow from systemic circulation. This allows localized therapy delivery to specific organs while preventing systemic distribution, thereby maintaining high local concentration without systemic side effects
Solution Approach 2:
The patent applies local quality by creating a localized therapy environment within the target organ through circulatory isolation. The occlusion devices enable different parts of the body to have different therapeutic conditions - the target organ receives high-concentration localized therapy while the rest of the body remains unaffected
2Reliability
If localized administration techniques are used, then therapy effectiveness is improved, but systemic side effects worsen due to convective transport
Solution Approach 1:
The patent uses occlusion devices to segment the circulatory system, creating an isolated compartment around the target organ. This segmentation prevents convective transport of therapy from the local site to systemic circulation, thereby eliminating systemic side effects while maintaining high local effectiveness
Solution Approach 2:
The occlusion devices act as intermediaries between the localized therapy site and systemic circulation. They physically block the convective transport pathway, serving as a mediator that allows localized therapy to be delivered without allowing therapy to reach systemic circulation
3Power
If aggressive treatments are administered, then treatment potency is improved, but systemic toxicity worsens
Solution Approach 1:
The patent segments circulation to enable delivery of aggressive treatments at high concentrations directly to the target organ while preventing these high concentrations from reaching systemic circulation, thereby eliminating systemic toxicity
Solution Approach 2:
The patent creates a localized high-concentration therapy environment within the target organ through circulatory isolation, allowing aggressive treatments to be administered at potent doses without exposing the rest of the body to toxic levels
4Reliability
If conventional cooling methods are used, then tissue protection is improved, but systemic adverse effects worsen
Solution Approach 1:
The patent segments the circulatory system to enable localized cooling of the target organ while isolating the cooling effect from systemic circulation, thereby preventing systemic adverse effects such as shivering and hemodynamic instability
Solution Approach 2:
The patent applies local quality by creating a localized cooling environment within the target organ through circulatory isolation, allowing therapeutic hypothermia to be delivered only where needed without causing systemic cooling and its associated adverse effects
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables localized therapy delivery with reduced systemic side effects, maintaining high organ-to-body gradients for extended periods, expanding the use of aggressive treatments like therapeutic hypothermia and chemotherapy.
Implementation Method 1
a distal portion of the catheter includes an occlusion device adapted to selectively substantially occlude the venous drainage structure
Implementation Method 2
a perfusion line terminating in a perfusion port operably disposed upstream from the occlusion device for delivering a perfusate to the isolated organ circulatory compartment
Implementation Method 3
a drainage line receiving venous drainage flow from the isolated organ circulatory compartment
Implementation Method 4
with optional blood conditioning to minimize systemic impact
Data Source
AI summary
A system for perfusing a localized site within a body includes a catheter assembly having a venous access line that is adapted to deliver perfusate to the localized site, a venous or arterial drainage line adapted to drain perfusate from the localized site, and an occlusion device adapted to prevent some or substantially all physiological blood flow between the localized site and the systemic circulation of the body during and in the course of perfusing and draining perfusate to and from the localized site. The system may include a blood circuit associated with the catheter assembly to facilitate blood conditioning for use as the perfusate, in the course of a controlled perfusion and/or drainage of untreated, treated, or inactivated treated blood to and from the localized site. A delivery machine may control the blood circuit and catheter assembly in order to both deliver perfusate to, and drain some or all perfusate from, the localized site in a manner that provides perfusate to substantially only the localized site.