Impedance Particle Counter Vacuum Control Without Regulators

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Solution Overview

Problem

Legacy particle counting systems, such as Coulter Counters, rely on bulky compressor pumps with vacuum regulators, which are expensive, noisy, and require manual adjustments, and often fail to detect issues like inadequate sweep flow priming and high sample volume requirements, leading to inaccurate particle counts.

Innovation Solution

The system employs stepper motor-controlled pumps like peristaltic, syringe, or helical pumps to create vacuum pressure, eliminating the need for vacuum regulators and using proportional-derivative negative feedback to maintain stable vacuum levels, along with diagnostics to detect blockages and ensure proper sweep flow.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If compressor pumps with vacuum regulators are used, then vacuum pressure can be maintained, but system complexity and cost increase

Engineering Contradiction:
Improvevacuum pressure maintenanceVSAvoidsystem complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent removes the vacuum regulator component from the system entirely. Instead of using a compressor pump with a vacuum regulator, the invention employs a peristaltic pump that inherently maintains vacuum pressure through its pumping mechanism, eliminating the need for the separate regulator component and reducing overall system complexity.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent replaces the mechanical compressor pump system with a peristaltic pump system. The peristaltic pump uses a different mechanical principle (peristalsis) to create vacuum, and when combined with electronic feedback control, achieves more precise and stable vacuum maintenance without requiring additional mechanical regulation components.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Reliability

If compressor pumps with vacuum regulators are used, then vacuum pressure can be maintained, but noise increases

Engineering Contradiction:
Improvevacuum pressure maintenanceVSAvoidnoise
Core Design Contradiction:
ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent replaces the noisy compressor pump mechanism with a peristaltic pump. Peristaltic pumps operate by rhythmic compression of tubing, which is inherently quieter than the reciprocating or rotary mechanisms of compressor pumps. This substitution maintains vacuum functionality while significantly reducing noise levels.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Reliability

If manual adjustments are required, then vacuum pressure can be regulated, but ease of operation decreases

Engineering Contradiction:
Improvevacuum pressure controlVSAvoidmanual adjustment requirement
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The patent implements an automatic feedback control system where a sensor continuously monitors vacuum pressure and sends signals to the processor, which then adjusts the peristaltic pump speed accordingly. This closed-loop feedback mechanism eliminates manual adjustments while maintaining precise vacuum pressure control, significantly improving ease of operation.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The system performs self-regulation of vacuum pressure through the feedback control loop. The processor automatically adjusts pump operation based on sensor input, allowing the system to maintain optimal vacuum levels without human intervention. This self-service capability eliminates the need for manual regulator adjustments.

Inventive Principle:
Principle #25Self-service

4Reliability

If sweep flow priming is not detected, then particle counting accuracy decreases

Engineering Contradiction:
Improvecounting accuracyVSAvoidsweep flow priming detection
Core Design Contradiction:
ReliabilityVSDifficulty of detecting and measuring

Solution Approach 1:

The patent uses the vacuum sensor as part of a feedback system to detect sweep flow priming status. By monitoring vacuum pressure characteristics, the system can infer whether the sweep flow is properly primed, providing indirect detection that improves counting accuracy without requiring complex direct measurement mechanisms.

Inventive Principle:
Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach reduces system complexity, noise, and cost while ensuring accurate particle counting by maintaining stable vacuum and detecting issues like tubing degradation and sweep flow priming, allowing for reduced sample volume requirements and improved counting accuracy.

Implementation Method 1

a pump configured to pull particles through the at least one sample aperture of the impedance particle counter for counting, the pump producing a vacuum pressure

Methodology Applied
Scientific EffectVacuum pressure: Vacuum

Implementation Method 2

The processor may be configured to adjust the stepper motor to adjust the speed of the pump according to a signal from the sensor. The processor may be further configured to adjust the stepper motor according to proportional-derivative negative feedback according to the signal from the sensor.

Methodology Applied
Scientific EffectProportional-derivative negative feedback: Feedback

Implementation Method 3

The impedance particle counter is configured to determine a count and size of the particles

Methodology Applied
Scientific EffectImpedance detection: Electrical Resistance

Implementation Method 4

The pump may be further configured to produce a sweep flow configured to move the particles away from the at least one sample aperture after counting

Methodology Applied
Scientific EffectSweep flow: Fluid Spray

Data Source

PatentUS20250347609A1Particle counting system
Publication Date: 2025.11.13 BECKMAN COULTER INC
  • US20250347609A1 patent drawing
  • US20250347609A1 patent drawing
  • US20250347609A1 patent drawing

AI summary

A biological particle counting system can include: an impedance particle counter comprising at least one sample aperture; a pump configured to pull particles through the at least one sample aperture of the impedance particle counter for counting, the pump producing a vacuum pressure; and a stepper motor configured to adjust a speed of the pump to substantially maintain the vacuum pressure.