Particle Size Distribution Estimation Using Chord Length Descriptors

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Solution Overview

Problem

Existing methods for predicting particle size distribution (PSD) and morphology based on chord length distribution (CLD) are inaccurate and imprecise due to variability in chord length measurements and require multiple models for different types of CLDs and morphologies, failing to handle morphological changes during in-line monitoring.

Innovation Solution

A system and method that estimates PSD and morphology using a computer system receiving multiple CLDs, employing a morphology estimation model, descriptor identifier, statistical model, and parameterized PSD model, which can handle various CLD types and morphologies, and adjusts parameters based on training datasets to generate accurate PSD and morphology estimates.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Device complexity

If a single model is used to predict PSD from CLD, then device complexity is reduced, but measurement precision deteriorates because existing models are specific to particular CLD types and particle morphologies

Engineering Contradiction:
Improvemodel complexityVSAvoidPSD prediction accuracy
Core Design Contradiction:
Device complexityVSMeasurement precision

Solution Approach 1:

The patent develops a universal prediction model that can handle multiple CLD types (e.g., Type A, Type B, Type C) and various particle morphologies (spherical, fibrous, plate-like, irregular) within a single framework. This multi-functional model eliminates the need for separate models for each CLD type and morphology combination, reducing device complexity while maintaining prediction accuracy through morphology identification and adaptive parameter adjustment

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent introduces morphology-dependent parameters and weighting factors that are dynamically adjusted based on the identified particle morphology. By changing parameters such as the relationship between chord length and particle diameter, and the weighting of different CLD moments, the model adapts to different morphology types, maintaining high prediction accuracy across diverse particle forms without requiring multiple separate models

Inventive Principle:
Principle #35Parameter changes

2Measurement precision

If multiple models are used for different CLD types and morphologies, then PSD prediction accuracy is improved, but device complexity increases

Engineering Contradiction:
ImprovePSD prediction accuracyVSAvoidmodel complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent merges multiple morphology-specific prediction approaches into a single unified model that incorporates morphology identification as a preliminary step. The system combines CLD data processing, morphology classification, and PSD prediction into an integrated framework where the model automatically selects appropriate parameters based on the identified morphology, effectively combining the advantages of multiple specialized models while avoiding their complexity

Inventive Principle:
Principle #5Merging (Combining)

3Measurement precision

If existing models are used for morphological changes, then they fail to identify morphology, but adapting models to handle morphological changes improves prediction accuracy

Engineering Contradiction:
Improvemorphology identification capabilityVSAvoidhandling morphological changes
Core Design Contradiction:
Measurement precisionVSAdaptability or versatility

Solution Approach 1:

The patent performs morphology identification as a preliminary step before PSD prediction. By first classifying the particle morphology based on CLD characteristics, the system prepares the appropriate parameters and weighting factors in advance, enabling accurate PSD prediction for the specific morphology type. This preliminary classification action allows the model to adapt to morphological changes without requiring complete model retraining

Inventive Principle:
Principle #10Preliminary action

Data Source

PatentUS10546243B1Predicting particle size distribution and particle morphology
Publication Date: 2020.01.28 MERCK SHARP & DOHME LLC
  • US10546243B1 patent drawing
  • US10546243B1 patent drawing
  • US10546243B1 patent drawing

AI summary

This disclosure relates to a method for estimating a particle size distribution (PSD) and a morphology for a set of particles. A computer system receives a plurality of chord length distributions (CLDs) of different types for a set of particles. The computer system then estimates a morphology for the set of particles based on the plurality of received CLDs. The computer system also identifies a plurality of descriptors of the plurality of CLDs for the set of particles based on the plurality of received CLDs. The computer system then estimates metrics for the PSD for the set of particles based on the plurality of identified CLD descriptors. Based on the estimated PSD metrics for the set of particles, the computer system generates an estimate of the PSD for the set of particles. Finally, the computer system outputs the estimated morphology and the estimated PSD for the set of particles.