Peach Blossom Fermentation Liquid for Opioid-Induced Constipation
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Solution Overview
Problem
There is a lack of products with good sensory organs and clear, significant efficacy in relieving slow transit constipation caused by opioid drugs.
Innovation Solution
A peach blossom fermentation liquid is prepared through a specific method involving soaking, decocting, enzymolysis, and dual fermentation with Saccharomyces cerevisiae and composite lactic acid bacteria, which enhances the bioavailability and palatability of active ingredients.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional Chinese medicine compositions are used to treat slow transit constipation, then constipation symptoms can be improved, but the bitter taste and bad smell make it difficult for patients to swallow and cause psychological repellence
Solution Approach 1:
The patent applies parameter changes by transforming the physical and chemical state of the medicinal materials through fermentation. The peach blossom fermentation liquid changes the taste parameters from bitter to sweet and sour, and the smell parameters from unpleasant to pleasant fruity aroma, while maintaining the therapeutic efficacy for treating constipation
Solution Approach 2:
The patent uses fermentation as an intermediary process that transforms the original medicinal materials into a more acceptable form. The fermentation process acts as a mediator that converts the bitter traditional Chinese medicine composition into a sweet and sour flavored liquid with pleasant aroma, bridging the gap between efficacy and palatability
2Reliability
If multiple traditional Chinese medicine materials are combined to treat slow transit constipation, then comprehensive symptom relief can be achieved, but excessive use of some medicinal materials may cause other functional intestinal diseases such as diarrhea
Solution Approach 1:
The fermentation process changes the pharmacological parameters of the medicinal materials. The complex mixture of traditional Chinese medicines is transformed through microbial fermentation into a balanced formulation where the active ingredients are modified, reducing the harsh effects while maintaining therapeutic benefits
Solution Approach 2:
The patent converts potentially harmful effects into beneficial ones through fermentation. The fermentation process transforms materials that could cause diarrhea into a balanced formulation that promotes healthy bowel movements. The fermentation byproducts and modified ingredients work synergistically to relieve constipation without causing intestinal dysfunction
3Reliability
If opioid drugs are used for analgesic treatment, then pain relief can be achieved, but excessive use causes adverse responses such as constipation, nausea and vomiting
Solution Approach 1:
The patent addresses opioid-induced constipation by using a fermentation-based solution that counteracts the harmful effects. The peach blossom fermentation liquid, produced through controlled fermentation, contains ingredients that specifically counterbalance the constipating effects of opioids while not interfering with their analgesic action
Solution Approach 2:
The fermentation liquid acts as an intermediary treatment that mediates between the necessary opioid analgesic therapy and the harmful constipating side effects. It provides a bridging solution that allows continued opioid use for pain management while simultaneously treating the gastrointestinal adverse effects
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The peach blossom fermentation liquid effectively improves slow transit constipation by promoting gastrointestinal motility, softening stools, and enhancing the absorption of nutrients, while also improving the taste and sensory qualities.
Implementation Method 1
inoculating Saccharomyces cerevisiae into the fermentation substrate for a primary fermentation
Implementation Method 2
inoculating composite lactic acid bacteria into the primary fermentation liquid for a secondary fermentation
Implementation Method 3
adding a flavor enzyme and a cellulase to the peach blossom liquid with dregs for enzymolysis
Data Source
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Figure 2(A)~2(C)
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AI summary
The present invention provides a peach blossom fermentation liquid for improving constipation, and a preparation method and use thereof, and relates to the field of traditional Chinese medicine processing. The preparation method includes: soaking dried peach blossom in water and then decocting to obtain a peach blossom liquid with dregs; adding a flavourzyme and a cellulase into the peach blossom liquid with dregs for enzymolysis, and inactivating the enzymes to obtain an enzymolysis dreg-liquid mixture; adding a carbon source into the enzymolysis dreg-liquid mixture, and sterilizing to obtain a fermentation substrate; inoculating Saccharomyces cerevisiae into the fermentation substrate for a primary fermentation, and sterilizing after the fermentation is completed to obtain a primary fermentation liquid; and inoculating composite lactic acid bacteria into the primary fermentation liquid for a secondary fermentation, sterilizing after the fermentation is completed, filtering, and concentrating to obtain the peach blossom fermentation liquid. The peach blossom fermentation liquid provided by the present invention improves the original strong bitter taste of peach blossom and has excellent sensory quality; has high content of active ingredients, rich nutrition and strong efficacy, can play the roles of relaxing bowels and promoting gastrointestinal motility, and especially has a clear and significant effect on improving constipation caused by opioid drugs.