Peptide Composition for Suppressing Muscular Atrophy

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Solution Overview

Problem

Current methods for preventing or improving muscular atrophy, such as high-intensity resistance training, are burdensome for elderly or recovering individuals, and there is a lack of effective nutritional approaches using dipeptides or tripeptides.

Innovation Solution

A composition comprising specific dipeptides (DI, IY, YN, NP) and tripeptides (DIY, IYN, YNP, NPQ, DFY, DIF, FYN, IFN, FNP, NPK) as active ingredients, which can be administered alone or in combination, to suppress muscular atrophy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If high intensity resistance training is used to prevent or improve muscular atrophy, then muscle function is improved, but physical burden increases significantly for elderly or recovering individuals

Engineering Contradiction:

Improveeffectiveness in preventing/improving muscular atrophyVSAvoidphysical burden on elderly or recovering individuals

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent replaces the mechanical exercise system with a chemical/nutritional system. Instead of using high-intensity resistance training (mechanical action on muscles), the invention uses specific dipeptides and tripeptides (chemical substances) to achieve the same goal of preventing and improving muscular atrophy. This substitution allows the therapeutic effect to be achieved without the physical burden of intense exercise, making it suitable for elderly or recovering individuals who cannot perform high-intensity training

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Reliability

If high intensity resistance training is used to prevent or improve muscular atrophy, then muscle function is improved, but expert instruction and proper supervision are required

Engineering Contradiction:

Improveeffectiveness in preventing/improving muscular atrophyVSAvoidneed for expert instruction and supervision

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent replaces the complex mechanical exercise system requiring expert supervision with a simple nutritional supplementation system. The dipeptides and tripeptides can be administered orally without requiring specialized knowledge or supervision, greatly simplifying the intervention process while maintaining effectiveness in preventing muscular atrophy

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

3Reliability

If proteins and amino acids are supplemented to prevent or improve muscular atrophy, then muscle function is improved, but no specific dipeptide or tripeptide has been reported to have muscular atrophy-suppressing effect

Engineering Contradiction:

Improveeffectiveness in preventing/improving muscular atrophyVSAvoidlack of specific effective dipeptide or tripeptide identification

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent segments the general protein/amino acid supplementation approach into specific dipeptides and tripeptides. Instead of using broad-spectrum proteins or individual amino acids, the invention identifies and utilizes specific short peptide sequences (dipeptides and tripeptides) that have demonstrated muscular atrophy-suppressing effects. This segmentation allows for more targeted and effective therapeutic intervention

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent changes the parameter of molecular size and structure by using dipeptides and tripeptides instead of larger proteins or individual amino acids. These smaller peptide molecules have specific properties that enhance their effectiveness in suppressing muscular atrophy, representing a parameter change from macromolecular proteins to small-molecule peptides with optimized bioavailability and activity

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS11331366B2Composition for suppressing muscular atrophy

Publication Date: 2022.05.17 OTSUKA PHARM CO LTD

AI summary

The present invention provides a composition for suppressing muscular atrophy, comprising as an active ingredient(s) one or more peptides selected from the group consisting of tripeptides DIY, IYN, YNP, NPQ, DFY, DIF, FYN, IFN, FNP, and NPK; the group consisting of dipeptides comprising F; and the group consisting of dipeptides DI, IY, YN, and NP.