Phytochemical Complexes with Biomolecules for Solubility
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Solution Overview
Problem
Current nutraceutical formulations of phytochemicals face challenges in solubility and bioavailability, limiting their therapeutic effectiveness when administered alone.
Innovation Solution
Complexing phytochemicals with proteins, peptides, amino acids, polysaccharides, disaccharides, or monosaccharides, using non-covalent conjugation methods, to enhance solubility and bioavailability, with specific examples including boswellic acid complexes with whey protein isolate, glucosamine sulfate, and chondroitin sulfate, facilitating administration in pharmaceutically acceptable excipients.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If phytochemicals are administered alone in nutraceutical formulations, then the formulations are simple to prepare, but the solubility and bioavailability are limited
Solution Approach 1:
The patent applies composite materials by combining phytochemicals with carriers such as proteins, peptides, amino acids, polysaccharides, disaccharides, or monosaccharides to form complexed nutraceutical formulations. This composite approach enhances the solubility and bioavailability of the phytochemicals while maintaining formulation simplicity through straightforward mixing processes in suitable solvents.
2Reliability
If phytochemicals are complexed with proteins, peptides, amino acids, polysaccharides, disaccharides, or monosaccharides, then solubility and bioavailability increase, but the formulation complexity increases
Solution Approach 1:
The patent employs carriers (proteins, peptides, amino acids, polysaccharides, disaccharides, or monosaccharides) as intermediaries to complex with phytochemicals. These intermediary substances enhance the solubility and bioavailability of the phytochemicals without requiring complex formulation processes, as the complexing is achieved through simple mixing in appropriate solvents.
3Reliability
If phytochemicals are complexed with biomolecules, then therapeutic effectiveness is enhanced, but the manufacturing process becomes more complex
Solution Approach 1:
The patent merges phytochemicals with biomolecules (proteins, peptides, amino acids, polysaccharides, disaccharides, or monosaccharides) to create complexed formulations that enhance therapeutic effectiveness. The merging process is simplified by using direct mixing in suitable solvents without requiring complex manufacturing steps, thus maintaining ease of manufacture while improving therapeutic outcomes.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The phytochemical complexes significantly increase solubility and serum bioavailability, allowing for more effective therapeutic delivery and alleviation of phytochemical-related disorders.
Implementation Method 1
Complexing phytochemicals with proteins, peptides, amino acids, polysaccharides, disaccharides, or monosaccharides, using non-covalent conjugation methods, to enhance solubility and bioavailability
Data Source
AI summary
The present invention provides a phytochemical complex comprising a therapeutically effective amount of boswellic acid; and one or more complexing agents conjugated to the therapeutically effective amount of boswellic acid, wherein the one or more complexing agents are selected from proteins, peptides, amino acids, polysaccharides, disaccharides, monosaccharides, amino sugars, glycosaminoglycans, and glycol-proteins, disposed in a pharmaceutically acceptable excipient, diluent, or carrier.