Pharmaceutical Non-Active Ingredients TRIZ Cases
- Water-Soluble PPE Synthesis via Palladium Catalyst
Palladium catalysis produces defect-free water-soluble polyphenyleneethynylene polymers in neat water without inert atmospheres.
- Lactose Cellulose Granules for Direct Tabletting
Atomizing lactose onto cellulose derivatives creates granules that resolve flow versus strength trade-offs in direct compression.
- Annexin 1-Binding Peptide for Tumor-Selective Drug Delivery
A peptide composition binds annexin 1 receptors on tumor vasculature to enable selective drug delivery.
- Protein-Polymer Composite Coating via Emulsion Crosslinking
Emulsion crosslinking entraps bioactive proteins in a polymer network to prevent denaturation while maintaining enzymatic activity at elevated temperatures.
- Organic-Aqueous Formulation for Mucosal Permeation
An organic-aqueous solvent mixture enhances phosphodiesterase inhibitor permeation across mucosal membranes.
- High Ester Pectin Capsule Film for Immediate Release
High ester pectin capsules replace gelatin and carrageenan, providing puncture strength and immediate drug release without animal-derived materials.
- Phytochemical Complexes with Biomolecules for Solubility
Complexing phytochemicals with proteins, peptides, or polysaccharides via non-covalent conjugation to form stable nutraceutical compositions.
- Multi-Arm Linker Conjugates for High Drug-to-Antibody Ratio
Segmented linkers boost therapeutic activity while hydrophilic spacers maintain water solubility.
- Phosphorylated Hexaacyl Disaccharide Adjuvant Stability
Replacing alum or MPL adjuvants with phosphorylated hexaacyl disaccharide derivatives reduces injection site reactions while maintaining immune response.
- Sweetener Composition Masking Hydrophobic Moieties
Masking hydrophobic backbones in organic scaffold particles reduces bitter aftertaste and improves temporal taste profiles for natural non-nutritive sweeteners.
- Amino Acid Peptide Steroid Conjugates for Ovarian Cancer
Enzymatic activation of peptide-steroid conjugates triggers self-assembly into nanofibers that interact with cancer cell membranes.
- Toroidal Mixed Nanoparticle for Targeted Drug Delivery
A toroidal mixed nanoparticle with elastic deformation enables effective penetration into blood vessels and tumor lesions.
- N3S1 Chelator-Folate Derivatives for Targeted Radiopharmaceutical Delivery
N3S1 chelator-folate derivatives bind radioisotopes to target alpha-folate receptors, enabling precise imaging and treatment of alpha-FR-positive tumors.
- Dual Lane Coating Surrogate Adjustment for Active Material Waste Reduction
Segmenting the process with a surrogate solution in the first lane eliminates active material waste during parameter adjustment.
- pH-Responsive Copolymer for Targeted Virus Release
A pH-dependent copolymer system reverses charge to release viruses in acidic environments.
- Low-Dose Drug Formulation via Oily Carrier Adhesion
An oily excipient binds low-dose drugs to a water-soluble carrier, achieving content uniformity without energy-intensive drying steps.