Plasma Spectroscopy Analysis for DMSA-Administered Specimens
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Solution Overview
Problem
The existing plasma spectroscopy analysis methods struggle to accurately measure particular metal ions, such as lead ions, in specimens collected after administration of meso-2,3-dimercaptosuccinic acid (DMSA) due to interference from co-substances, leading to reduced measurement sensitivity.
Innovation Solution
A plasma spectroscopy analysis method that includes a preliminary addition process of an auxiliary chelating agent, such as EDTA, to specimens collected from bodies administered with DMSA, followed by a concentration process using electrodes and a detection process that generates plasma luminescence for accurate quantification of heavy metal ions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If DMSA is administered to a patient and urine specimens are collected for metal ion measurement, then heavy metal ions can be excreted and measured, but co-substances interfere with the measurement causing reduced sensitivity and inaccurate results
Solution Approach 1:
The patent extracts and removes the harmful co-substances (interfering substances) from the specimen through a purification step before measurement. This is achieved by adding a bonding agent that selectively binds to interfering substances, allowing them to be separated from the metal ions of interest, thereby eliminating the interference and improving measurement accuracy
Solution Approach 2:
The patent introduces a bonding agent as an intermediary substance that mediates between the interfering co-substances and the measurement process. This bonding agent selectively binds to interfering substances without affecting metal ion detection, acting as a mediator that removes harmful interference while preserving the integrity of the target analyte measurement
2Productivity
If conventional plasma spectroscopy analysis is used on specimens from DMSA-administered patients, then the analysis process is simple and quick, but measurement sensitivity for particular metal ions such as lead ions is reduced
Solution Approach 1:
The patent applies preliminary action by performing a purification step before the plasma spectroscopy measurement. The bonding agent is added and allowed to bind to interfering substances prior to analysis, pre-removing the sources of interference. This preliminary treatment enables subsequent rapid measurement with restored sensitivity, combining the speed of conventional analysis with improved accuracy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method enables accurate measurement of lead ions without sensitivity reduction, as evidenced by improved correlation with graphite furnace atomic absorption spectrometry results, demonstrating enhanced detection capabilities.
Implementation Method 1
adding a bonding agent which is capable of bonding with analyte heavy metal ions to a specimen
Implementation Method 2
concentrating the analyte heavy metal ions in the specimen at a vicinity of one of a pair of electrodes by applying a voltage to the pair of electrodes
Implementation Method 3
generating plasma by applying a voltage to the pair of electrodes, and detecting luminescence of the analyte heavy metal ions caused by the plasma
Data Source
AI summary
A plasma spectroscopy analysis method includes a preliminary addition process in which a bonding agent that is an agent other than DMSA is added to the specimen collected from a living body to which meso-2,3-dimercaptosuccinic acid (DMSA) is administered, a concentration process in which the analyte heavy metal ions in the specimen at a vicinity of one of a pair of electrodes by applying a voltage to the pair of electrodes, and a detection process in which plasma is generated by applying a voltage to the pair of electrodes, and luminescence of the analyte metal ions caused by the plasma is detected.