Polyacrylic Acid Adhesive Matrix for Wet Tissue Sealing
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Solution Overview
Problem
Commercially available tissue sealants and hemostatic agents are inadequate in wet or 'bleeding' applications due to slow performance, lack of adhesive properties, and insufficient tensile strength for effective arterial blood loss prevention.
Innovation Solution
Development of adhesive compositions comprising a mixture of polyacrylic acid crosslinked with pentaerythritol and divinyl glycol, using a non-aqueous solvent like ethanol, which forms a strong, cohesive, and biocompatible adhesive matrix with low residual solvent content, enhancing adherence and mechanical strength.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If commercially available tissue sealants are used, then they provide basic sealant properties, but they are too slow and lack sufficient tensile strength for arterial blood loss prevention
Solution Approach 1:
The patent changes the chemical composition parameters by using polyacrylic acid crosslinked with pentaerythritol and divinyl glycol, and controls the water content at less than or equal to 2 wt.%, to achieve both high strength and rapid setting without the trade-off present in conventional sealants
Solution Approach 2:
The patent creates a composite adhesive matrix combining polyacrylic acid with specific crosslinking agents (pentaerythritol and divinyl glycol) to achieve superior mechanical properties and rapid setting characteristics that overcome the limitations of single-component commercial sealants
2Reliability
If commercially available tissue sealants are used, then they are easy to apply, but they lack adhesive properties in wet or bleeding applications
Solution Approach 1:
The patent changes the chemical parameters by using non-aqueous solvents (at least about 90 wt. % ethanol) and maintaining water content at less than or equal to 2 wt.%, enabling the adhesive to maintain its properties and provide reliable adhesion in wet or bleeding surgical conditions
3Productivity
If commercially available sealants are used, then they provide basic hemostatic function, but they are too cumbersome for effective use
Solution Approach 1:
The patent develops a composite adhesive composition with polyacrylic acid crosslinked with pentaerythritol and divinyl glycol that provides superior hemostatic efficiency and tissue sealing performance while maintaining simple application procedures, eliminating the cumbersome nature of existing sealants
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting adhesive matrix demonstrates superior adhesive and mechanical properties, including high burst strength and lap shear adhesive strength, suitable for effective tissue sealing and hemostasis in challenging clinical conditions.
Implementation Method 1
allowing at least a portion of the non-aqueous liquid and the non-aqueous polar solvent to evaporate to produce the adhesive matrix
Data Source
AI summary
Adhesive compositions and patches, and associated systems, kits, and methods, are generally described. Certain of the adhesive compositions and patches can be used to treat tissues (e.g., in hemostatic or other tissue treatment applications), according to certain embodiments.