Polyphenol-Biomolecule Complexes for Enhanced Bioavailability

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Solution Overview

Problem

Current nutraceutical formulations of polyphenols face challenges in solubility and bioavailability, limiting their therapeutic effectiveness due to poor absorption and rapid metabolism.

Innovation Solution

Polyphenols are complexed with proteins, peptides, amino acids, polysaccharides, disaccharides, or monosaccharides to enhance solubility and bioavailability, forming therapeutically effective nutraceutical compositions that can be administered in a pharmaceutically acceptable excipient, diluent, or carrier.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If polyphenols are used in nutraceutical formulations, then therapeutic efficacy is improved, but solubility and bioavailability deteriorate

Engineering Contradiction:

Improvetherapeutic efficacyVSAvoidsolubility

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent applies composite materials by combining polyphenols with proteins, peptides, amino acids, polysaccharides, disaccharides, or monosaccharides to form complexes. This composite approach resolves the solubility issue while maintaining therapeutic efficacy, as the complexed form of polyphenols exhibits improved solubility and bioavailability compared to free polyphenols.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent uses proteins, peptides, amino acids, polysaccharides, disaccharides, or monosaccharides as intermediary substances that mediate between polyphenols and the biological system. These intermediaries facilitate improved solubility and absorption of polyphenols, thereby enhancing bioavailability while preserving therapeutic effects.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If polyphenols are used in nutraceutical formulations, then therapeutic efficacy is improved, but absorption and bioavailability deteriorate

Engineering Contradiction:

Improvetherapeutic efficacyVSAvoidabsorption

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent employs composite materials by forming complexes between polyphenols and biomolecules (proteins, peptides, amino acids, polysaccharides, disaccharides, or monosaccharides). This composite structure enhances absorption and bioavailability, directly addressing the technical contradiction between therapeutic efficacy and absorption performance.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent utilizes biomolecules as intermediary substances that facilitate the absorption process. These intermediaries (proteins, peptides, amino acids, polysaccharides, disaccharides, or monosaccharides) act as carriers that improve the bioavailability of polyphenols, thereby enhancing absorption while maintaining therapeutic efficacy.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Reliability

If polyphenols are used in nutraceutical formulations, then therapeutic efficacy is improved, but rapid metabolism deteriorates

Engineering Contradiction:

Improvetherapeutic efficacyVSAvoidduration of action

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent applies composite materials by creating polyphenol-biomolecule complexes. This composite approach slows down metabolism and extends the duration of action of polyphenols in the body, as the complexed form is metabolized more slowly compared to free polyphenols, thereby maintaining therapeutic efficacy for a longer period.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent uses biomolecules as intermediary substances that modulate the metabolism of polyphenols. These intermediaries (proteins, peptides, amino acids, polysaccharides, disaccharides, or monosaccharides) act as protective carriers that reduce rapid metabolism and extend the duration of action of polyphenols, thereby maintaining therapeutic effects over time.

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The polyphenol complexes significantly increase serum bioavailability and therapeutic efficacy by improving solubility and absorption, allowing for more effective treatment of polyphenol-related disorders.

Implementation Method 1

Polyphenols are complexed with proteins, peptides, amino acids, polysaccharides, disaccharides, or monosaccharides to enhance solubility and bioavailability

Methodology Applied

Scientific EffectComplexation:

Implementation Method 2

The polyphenol complexes significantly increase serum bioavailability and therapeutic efficacy by improving solubility and absorption

Methodology Applied

Scientific EffectSolubility enhancement: Solvation

Data Source

PatentUS20250018044A1Methods of Making and Using Polyphenols Complexed With a Protein, Peptide, Amino Acid, Polysaccharide, Disaccharide, or Monosaccharide

Publication Date: 2025.01.16 CHANCEY JOHN ROBERT

AI summary

The present invention a polyphenol complexes with amino acids, peptides, proteins, glycosaminoglycans, polysaccharides, mucopolysaccharide, disaccharides, monosaccharides, amino sugars, glycol-proteins, DNA/RNA oligonucleotides, mRNA, siRNA, antibodiesor other micro- or macro biomolecules.