Porous Adsorbate Formulation for Stable 3-Nitrooxypropanol Retention
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Solution Overview
Problem
3-nitrooxypropanol and its derivatives are not efficiently retained in standard carrier systems used in the feed industry under conventional storage conditions, leading to significant loss of the active compound and increased costs due to the need for elaborate packaging and small dosage units.
Innovation Solution
A process for producing adsorbates by applying a mixture of 3-nitrooxypropanol derivatives, gelatin, and optional edible solvent to a carrier, ensuring at least 10-80 wt-% of the components are present in the carrier's internal pore volume, enhancing storage stability and retention.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If standard carrier systems are used for storage, then the product is easy to handle and store, but the active compound is not efficiently retained leading to significant loss during storage
Solution Approach 1:
The patent utilizes porous silica gel as the carrier system. The porous structure provides internal pore volume where the active compound (3-nitrooxypropanol) is retained through adsorption. This porous material structure enables both easy handling/storage and efficient retention of the active compound, resolving the contradiction between storage convenience and compound stability.
Solution Approach 2:
The patent creates a composite adsorbate system combining silica gel carrier with gelatin and the active compound. This composite formulation enhances the retention capability while maintaining the free-flowing characteristics and ease of handling. The composite structure allows the active compound to be held securely during storage without requiring elaborate packaging.
2Reliability
If elaborate packaging systems are used to minimize loss of active, then storage stability is improved, but the device complexity and cost increase
Solution Approach 1:
The adsorbate formulation itself provides the retention function through its composition. The gelatin and porous silica gel structure work together to hold the active compound without requiring external elaborate packaging systems. The product is self-protecting during storage, eliminating the need for complex packaging while maintaining high retention rates.
3Reliability
If small dosage units are used to minimize loss after opening, then retention is improved, but the manufacturing cost increases
Solution Approach 1:
The porous silica gel structure provides a large surface area and internal pore volume that retains the active compound even in larger dosage units. This eliminates the need for small dosage units, allowing standard manufacturing scales while maintaining retention performance and reducing manufacturing costs.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adsorbates exhibit improved handling and storage stability, retaining at least 90-95% of the active compound over 12 weeks, allowing for cost-effective, free-flowing, and industrially handleable product forms without significant loss during storage.
Implementation Method 1
a mixture comprising at least a compound of formula (I)... and gelatin (G) optionally in the presence of an edible solvent (S) and/or further conventional additives (A) is applied to a carrier (C)... at least 10 wt.-%, in particular at least 20 wt.-%, preferably at least 30 wt.-%, particularly preferably at least 40 wt.-%, in particular at least 50 wt.-% of the components to be adsorbed... are present in the internal pore volume of the carrier (C)
Data Source
AI summary
The present invention relates to storage stable adsorbates of 3-nitrooxypropanol and derivatives thereof as well as to the production of such adsorbates.