Hydratable Bone Putty Using Porous Ceramic Granules for Cohesive Injection
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Solution Overview
Problem
Existing bone cements and putties face challenges in maintaining cohesiveness and stability due to the incorporation of large, non-uniform ceramic particles, which disrupt the composition's handling and cohesion, making it difficult to convert between putty, paste, non-settable flowable cement, or gel forms.
Innovation Solution
A composition comprising porous ceramic granules with a diameter of 50μm to 800μm, made from hydroxyapatite and beta-tricalcium phosphate, combined with a collagen carrier, allows conversion between putty, paste, non-settable flowable cement, or gel forms, maintaining stability and flexibility for surgical administration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If large hard ceramic pieces are incorporated into the composition, then bone growth is stimulated, but the composition becomes unstable and lacks cohesiveness for handling
Solution Approach 1:
The ceramic material is divided into small granules (50-800 micrometers) rather than using large hard pieces, allowing the ceramic to maintain bone growth stimulation while fitting within a cohesive matrix that can be handled
Solution Approach 2:
Porous ceramic granules are used instead of dense ceramic pieces, allowing the ceramic to be incorporated in substantial amounts while maintaining composition stability and cohesiveness through the porous structure that facilitates bonding with the polymer matrix
2Ease of operation
If additional fluid is added to an already formed bone putty, then the putty becomes flowable and injectable, but the over hydrated putty lacks cohesion and disintegrates
Solution Approach 1:
The composition is designed to dynamically change its rheological properties based on hydration level, transitioning from a putty state (low hydration) to a flowable cement state (high hydration) while maintaining cohesion at both extremes through the porous ceramic granule structure
Solution Approach 2:
The composition utilizes changes in hydration parameters to control the transition between different states (putty, paste, flowable cement, gel), allowing the same base composition to exhibit different rheological properties without losing cohesion
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides stable and moldable bone void fillers that can be administered through cannulas or syringes, ensuring cohesive handling and effective bone growth stimulation.
Implementation Method 1
These compositions may, depending upon the materials contained within them, be used to repair tissues and to impart desirable biological and/or mechanical properties
Implementation Method 2
The hydratable putty comprises porous ceramic granules having an average diameter from about 50μm to 800μm. The porous ceramic granules comprise hydroxyapatite and beta-tricalcium phosphate. The composition further includes a collagen carrier.
Implementation Method 3
the composition can be hydrated with a fluid to form a stable bone putty, where, if desired, the bone putty can be further hydrated with a fluid to form a stable and non-settable flowable cement or gel
Data Source
AI summary
Implantable bone compositions are provided. The implantable compositions comprise hydratable bone putties. The hydratable bone putties comprise porous ceramic granules having an average diameter from about 50 μm to 800 μm and the composition has a texture value above about 1000. The porous ceramic granules comprise hydroxyapatite and beta-tricalcium phosphate. The implantable bone compositions further include collagen carriers. In some embodiments, the hydratable bone putty can be hydrated to form a non-settable flowable cohesive cement or gel. Methods of making and using the implantable compositions are also provided.