Powdered Polymeric Hemostatic Composition and Spring-Loaded Delivery Device
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Solution Overview
Problem
Current medical compositions for preventing excessive bleeding during surgery often require aqueous carriers and active agents like thrombin, are not biodegradable, and lack user control in delivery, making them inefficient and complex to use, especially in emergency situations.
Innovation Solution
Development of powdered polymeric compositions that form a hydrogel when exposed to blood, eliminating the need for aqueous carriers and active agents, and a delivery system with a spring cap assembly for precise administration of these compositions to the bleeding site.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If aqueous carrier compositions are used to prevent excessive bleeding, then the compositions can be delivered in powder form with optimized release characteristics, but additional preparation steps are required which are undesirable in emergency situations
Solution Approach 1:
The invention extracts and eliminates the aqueous carrier component from the composition, transforming it from a liquid-based system requiring reconstitution to a dry powder system ready for immediate use. This removal of the carrier phase resolves the contradiction by maintaining manufacturability while eliminating preparation steps.
Solution Approach 2:
The active agents and polymeric materials are pre-formulated and dried into powder form during manufacturing, with release characteristics optimized in advance. This preliminary preparation during production eliminates the need for post-manufacturing preparation steps, allowing immediate use in emergency situations.
2Reliability
If aqueous carrier compositions with active agents like thrombin are used, then bleeding prevention can be achieved, but unwanted additional preparation and delivery steps are required
Solution Approach 1:
The invention merges the active hemostatic agents with the polymeric carrier material into a single integrated dry powder composition. This combination eliminates the need for separate preparation of active agents and carriers, reducing delivery steps while maintaining bleeding prevention effectiveness through the synergistic interaction of components upon contact with blood.
Solution Approach 2:
The composition is designed to be self-activating upon contact with blood, eliminating the need for external activation steps. The dry powder automatically rehydrates and activates the hemostatic agents through contact with physiological fluids, providing reliable bleeding prevention without additional preparation or delivery complexity.
3Adaptability or versatility
If non-solid anti-adhesive materials are used, then the materials can be sufficiently fluid to enter and conform to the regions being treated, but they may not remain sufficiently viscous to stay on the bleeding site until healing
Solution Approach 1:
The invention employs a dynamic viscosity system where the material transitions from a dry powder state (easy to apply) to a gel state upon contact with blood. The material initially flows to conform to the treatment region, then automatically increases its viscosity and structural integrity through hydration and polymer network formation, maintaining stability at the bleeding site throughout the healing process.
4Reliability
If materials that are not biodegradable are used for bleeding prevention, then the materials can provide stable hemostasis, but they remain in the body with unpredictable and potentially undesirable consequences
Solution Approach 1:
The invention uses biodegradable polymeric materials with carefully controlled degradation parameters that match the healing timeline. The materials provide stable hemostasis during the critical period through their structural integrity, then gradually degrade into harmless byproducts as tissue healing progresses, eliminating long-term foreign body presence and associated risks.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The powdered polymeric compositions effectively inhibit bleeding by forming a hydrogel that promotes hemostasis without the need for thrombin, providing a biodegradable and user-controlled delivery method that is simpler and more efficient than existing solutions.
Implementation Method 1
The material includes a biologically compatible polymer (which may be cross-linked or non-crosslinked, or have both cross-linked and non-cross-linked components), which forms a hydrogel when exposed to blood
Data Source
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AI summary
Polymeric compositions, methods, and delivery devices for inhibiting bleeding are disclosed. The method includes applying a dried material topically to a wound site, where the material may include a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood and where the material may not include an active agent such as thrombin. A spring-loaded delivery device as described herein may be used to apply the dried material.