Prevotella Copri Formulations with Diet-Matched Polysaccharide Utilization
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Solution Overview
Problem
Current probiotic formulations for addressing microbiome imbalances in childhood undernutrition are not tailored to specific populations and diet contexts, leading to modest effects in correcting long-term sequelae such as stunting and impaired immune responses.
Innovation Solution
Development of probiotic compositions comprising Prevotella copri strains with enhanced polysaccharide utilization loci, administered with microbiome-directed therapeutic foods, to enhance utilization of specific carbohydrates and modify the gut microbiota.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If generic probiotic formulations are used to address microbiome imbalances in undernourished children, then broad coverage of probiotic strains is achieved, but the effectiveness in correcting long-term sequelae such as stunting and impaired immune responses is limited
Solution Approach 1:
The patent applies local quality by identifying and isolating specific Prevotella copri strains with particular polysaccharide utilization capabilities that are locally adapted to the dietary contexts of undernourished children. Rather than using generic probiotic formulations, the invention focuses on strains with specific genomic characteristics (polysaccharide utilization loci) that match the nutritional needs of target populations, thereby improving both adaptability and reliability simultaneously
2Reliability
If probiotic formulations are tailored to specific populations and diet contexts, then effectiveness in correcting microbiome imbalances is improved, but the complexity of formulation development and customization increases
Solution Approach 1:
The patent applies parameter changes by using genomic parameters (polysaccharide utilization loci sequences) as selection criteria for probiotic strains. This provides an objective, measurable parameter for tailoring formulations to specific populations and diets, improving effectiveness while reducing the subjective complexity of formulation development through standardized genomic-based selection
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compositions effectively enhance nutrient uptake and modify the gut microbiota, improving growth outcomes and immune function in undernourished children, addressing symptoms of malnutrition and associated health issues.
Implementation Method 1
the probiotic bacterial strain comprises at least two, at least three, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10 or at least 20, at least 30 or more of a polynucleotide sequence encoding a protein from one or more of the polysaccharide utilization loci PUL3a, PUL3b, PUL9, PUL10, PUL15, PUL16, PUL17, PUL18, PUL 19, PUL20, PUL22, or PUL30
Data Source
AI summary
Provided are probiotic compositions and methods of using such compositions for treatment of a spectrum of diseases like malnutrition. The probiotic compositions provided herein have Prevotella copri or engineered strains with genes from Prevotella copri.