Pridopidine Periodic Administration for Cognitive Function
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Solution Overview
Problem
Current treatments for cognitive deficits associated with various diseases and disorders, such as Alzheimer's, schizophrenia, and Parkinson's, are inadequate in effectively improving memory and cognitive function.
Innovation Solution
A pharmaceutical composition comprising pridopidine or its pharmaceutically acceptable salt, administered periodically, which enhances memory by modulating dopamine transmissions and acetylcholine levels, thereby improving short-term and working memory in subjects with cognitive deficits.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments for cognitive deficits are used, then existing therapy options are available, but memory and cognitive function are not effectively improved
Solution Approach 1:
Pridopidine is presented as a dopaminergic stabilizer with broad applicability across multiple neurological and psychiatric conditions including Alzheimer's disease, Parkinson's disease, schizophrenia, and Huntington's disease. The compound stabilizes dopamine transmission in both hyperactive and hypoactive states, making it a universal treatment option for diverse cognitive impairments rather than being limited to a single condition.
Solution Approach 2:
The invention changes the pharmacological parameter of dopamine transmission stability by introducing pridopidine, a dopaminergic stabilizer that modulates dopamine activity. This parameter change addresses the inadequacy of current treatments by providing a mechanism that stabilizes dopaminergic function across different disease states, thereby improving memory and cognitive function effectiveness.
2Reliability
If pridopidine is administered to improve memory, then cognitive function is enhanced, but the mechanism involves complex modulation of dopamine and acetylcholine systems
Solution Approach 1:
Pridopidine acts as an intermediary substance that mediates between imbalanced dopaminergic systems and cognitive function. As a dopaminergic stabilizer, it indirectly regulates acetylcholine levels and neuronal health through its primary action on dopamine transmission, simplifying the therapeutic approach by using a single compound that triggers multiple beneficial downstream effects rather than requiring complex combination therapies.
Data Source
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AI summary
This invention provides a method of improving cognitive function in a subject comprising periodically administering to the subject an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to improve a cognitive function in the subject. The invention also provides a method of treating a subject afflicted with Alzheimer's disease, comprising periodically administering to the subject a pharmaceutical composition comprising an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to treat the subject.