Probiotic Bacillus Isolates for Poultry Digestion and Nutrient Absorption
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Solution Overview
Problem
Monogastric agricultural animals, such as poultry and swine, face digestive issues due to non-digestible nutrients like non-starch polysaccharides and damaged proteins in feed, leading to gut inflammation, opportunistic pathogen overgrowth, and poor performance, which traditional antibiotics can't effectively address without environmental and health concerns.
Innovation Solution
A probiotic composition containing enzyme-producing Bacillus isolates like Bacillus amyloliquefaciens JD17 and Bacillus licheniformis AM1002, which break down non-digestible nutrients, improving digestion and nutrient absorption when added to animal feed, reducing feed viscosity and bacterial translocation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If non-digestible nutrients like non-starch polysaccharides and damaged proteins are present in feed, then feed formulation flexibility is improved, but digestion and nutrient absorption deteriorate
Solution Approach 1:
The patent uses multiple different enzyme types (phytase, protease, lipase, cellulase, hemicellulase, xylanase) to break down different types of non-digestible nutrients into smaller, absorbable components. This segmentation approach allows the feed to maintain formulation flexibility while improving digestibility through targeted enzymatic breakdown of complex molecules.
Solution Approach 2:
The patent introduces probiotic microorganisms as intermediary agents that produce enzymes to facilitate the breakdown of non-digestible nutrients. These microorganisms act as mediators between the feed ingredients and the animal's digestive system, enabling flexible feed formulations to be digested effectively without requiring changes to the feed composition itself.
2Reliability
If antibiotics are used to control gut health issues, then pathogen overgrowth is reduced, but environmental and health concerns increase
Solution Approach 1:
The patent converts the harmful effect of non-digestible nutrients (which cause pathogen overgrowth and gut inflammation) into a beneficial outcome by using probiotic microorganisms to produce enzymes that break down these nutrients before they can cause harm. This transforms the problematic non-digestible components into useful substrates for probiotic growth and enzyme production, eliminating the need for antibiotics.
Solution Approach 2:
The probiotic microorganisms in the patent perform self-service by producing their own enzymes to break down non-digestible nutrients and create a healthy gut environment. This self-service mechanism eliminates the need for external antibiotic intervention, allowing the system to maintain gut health through its own metabolic activities while avoiding the environmental and health concerns associated with antibiotic use.
3Loss of energy
If grains high in NSP are substituted for corn, then feed cost is reduced, but digesta viscosity and gut inflammation increase
Solution Approach 1:
The patent changes the physical-chemical parameters of non-digestible nutrients through enzymatic modification. Phytase converts phytate to inositol, cellulase breaks down cellulose, hemicellulase degrades hemicellulose, and xylanase cleaves xylan. These parameter changes reduce digesta viscosity and prevent gut inflammation, allowing the use of cost-effective grains high in NSP without the negative effects.
4Reliability
If enzymes are added to break down non-digestible substrates, then nutrient digestibility is improved, but feed formulation complexity increases
Solution Approach 1:
The patent merges multiple enzyme functions into a single probiotic formulation containing multiple microorganism strains. Instead of adding separate enzyme products for phytase, protease, lipase, cellulase, hemicellulase, and xylanase activities, the patent combines these functions in one integrated probiotic product, simplifying feed formulation while maintaining comprehensive nutrient digestibility improvement.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The probiotic composition enhances body weight gain, bone strength, and feed efficiency by improving nutrient digestibility and absorption, while reducing intestinal viscosity and bacterial translocation, thus addressing the limitations of traditional antibiotic use.
Implementation Method 1
at least two enzyme producing Bacillus isolates selected from Bacillus amyloliquefaciens JD17, Bacillus licheniformis AM1002, Bacillus amyloliquefaciens AM0938, Bacillus amyloliquefaciens AM1109B, Bacillus amyloliquefaciens AM1101, Bacillus amyloliquefaciens AM0939, Bacillus amyloliquefaciens AM0934, Bacillus amyloliquefaciens AM0933, or Bacillus amyloliquefaciens AM0940
Implementation Method 2
These include products containing enzymes that attack or breakdown non-starch polysaccharides (NSPase), hemicellulose (hemicellulase), xylan (xylanases), protein (proteases)
Data Source
AI summary
The present disclosure relates to probiotic compositions, formulations and methods for promoting digestion and improving nutrition in birds, and probiotic compositions and formulations for increasing enzyme production and improving parameters and indications in birds.