Probiotic-Butyrate Feed Composition for Enterocyte Uptake
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Solution Overview
Problem
The uptake of butyric acid or its salts at the intestinal level is impaired by inflammatory conditions, particularly in animals fed with high-fat diets, leading to reduced enterocyte health and overall wellness.
Innovation Solution
Simultaneously administering a probiotic, specifically Enterococcus faecium strain NCIMB 10415, with butyric acid or its salts, such as sodium butyrate, to enhance enterocyte uptake and improve intestinal health.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If butyric acid or its salts are administered to animals, then intestinal tissue health should be improved, but uptake is impaired by inflammatory conditions and high-fat diets
Solution Approach 1:
The probiotic Enterococcus faecium SF68 acts as an intermediary that restores the intestinal environment, thereby enabling butyric acid uptake. The probiotic modifies the intestinal conditions by reducing inflammation and improving barrier function, which indirectly facilitates the uptake of butyric acid without directly interacting with it.
Solution Approach 2:
The probiotic is administered beforehand to prepare the intestinal environment for butyric acid uptake. By pre-treating the intestinal tissue with the probiotic, the inflammatory conditions are mitigated and the uptake mechanism is restored before butyric acid administration becomes effective.
2Use of energy by moving object
If high-fat diet is fed to animals, then energy intake is increased, but intestinal tissue damage and inflammation occur
Solution Approach 1:
The probiotic converts the harmful effects of high-fat diet-induced inflammation into beneficial outcomes by restoring intestinal barrier function and reducing inflammatory markers. The same high-fat diet conditions that cause damage become the backdrop against which the probiotic demonstrates its restorative capabilities, ultimately enabling better nutrient utilization including butyric acid uptake.
3Reliability
If probiotic and butyric acid are both administered, then enterocyte health is improved, but feed formulation complexity increases
Solution Approach 1:
The probiotic Enterococcus faecium SF68 and butyric acid are merged into a single feed supplement formulation. This combination product integrates two active ingredients that work synergistically - the probiotic prepares the intestinal environment while butyric acid provides direct nutritional support to enterocytes, achieving enhanced health outcomes through a unified feed additive solution.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances enterocyte health, resulting in improved weight gain and physiological and behavioral parameters in pets and livestock, as demonstrated by experimental studies on mice and chickens.
Implementation Method 1
the animal needs to adsorb butyric acid or its salts through an uptake mechanism of this short chain fatty acid (SCFA) into the enterocytes
Implementation Method 2
the animal needs to adsorb butyric acid or its salts through an uptake mechanism of this short chain fatty acid (SCFA) into the enterocytes
Data Source
AI summary
The use of a probiotic, particularly the Enterococcus faecium strain NCIMB 10415 which is named SF68® as probiotic active ingredient, in combination with butyric acid or a salt thereof to increase the enterocyte's health and consequently the wellness of pets and livestock is described.