Rebaudioside D Crystallization with Selective Supersaturation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing methods for producing rebaudioside D-containing crystallized products face challenges in achieving high purity and yield ratios due to the higher content of rebaudioside A compared to rebaudioside D in stevia plant extracts, leading to entrainment of rebaudioside D in rebaudioside A crystallization.
Innovation Solution
A method involving the use of a roughly purified stevia plant extract with a total steviol glycoside content of 50 to 95% by mass, adjusting the solvent supersaturation levels for rebaudioside A and D, and controlled cooling to precipitate rebaudioside D, using methanol or ethanol as solvents, and optionally seed crystals to enhance crystallization.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional crystallization methods are used to purify rebaudioside D, then rebaudioside A is preferentially crystallized due to its higher content, but rebaudioside D becomes entrained and cannot be effectively separated
Solution Approach 1:
The invention changes the crystallization parameters by controlling the degree of supersaturation of rebaudioside D to be 10 or more while keeping rebaudioside A at 18 or less, and by adjusting cooling rates and temperatures. This selective parameter control enables rebaudioside D to crystallize preferentially despite its lower concentration, resolving the contradiction between purity and yield
Solution Approach 2:
The invention performs preliminary purification of the stevia extract to concentrate rebaudioside D and remove impurities before crystallization. This preliminary action creates optimal conditions for subsequent selective crystallization, enabling high purity and high yield of rebaudioside D by preparing the material in advance
2Manufacturing precision
If multiple consecutive crystallization steps are performed to improve purity, then the purification effectiveness increases, but the production time and process complexity increase significantly
Solution Approach 1:
The invention performs comprehensive preliminary purification including extraction, concentration, and impurity removal before the crystallization step. This preliminary action ensures that a single crystallization step under controlled conditions achieves high purity, eliminating the need for multiple consecutive crystallization cycles and thereby reducing production time
Solution Approach 2:
The invention optimizes crystallization parameters including supersaturation degree, cooling rate, and temperature to maximize purity in a single crystallization step. By carefully controlling these parameters, the process achieves high purification effectiveness without requiring multiple repeated steps, thus reducing overall production time
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method achieves a rebaudioside D-containing crystallized product with high purity and yield ratios, overcoming the limitations of conventional methods by directly crystallizing rebaudioside D from a roughly purified product.
Implementation Method 1
adjusting the solvent supersaturation levels for rebaudioside A and D
Implementation Method 2
cooling the solution for crystallization with stirring, to precipitate rebaudioside D
Data Source
Figure 1
Figure 2~3
Figure 4~5
AI summary
There is demand for a novel method for manufacturing a RebD crystallized product. The present invention provides a method for manufacturing a RebD-containing crystallized product, including: a step for mixing a stevia plant-derived crude product having a total steviol glycoside content of 50-95 mass%, and containing at least RebA and RebD, into a solvent containing methanol or ethanol so that the supersaturation of RebD at 10°C is at least 10 and the supersaturation of RebA at 10°C does not exceed 18, and adjusting a crystallization solution; and a step for cooling the crystallization solution under stirring and causing RebD to precipitate.