Recombinant lactic acid bacterium and method thereof for simultaneous treatment and/or prevention of dust mite and cockroach allergies
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Solution Overview
Problem
Current methods for preventing and treating dust mite and cockroach allergies primarily focus on environmental control, which are inadequate in completely blocking allergens from contacting the human body, leading to potential allergic reactions and discomfort or severe health issues.
Innovation Solution
A recombinant lactic acid bacterium, such as Lactococcus, is engineered to express proteins derived from dust mite and cockroach allergens, inducing antibody production to counteract these allergens through administration as a food, vaccine, or nutritional supplement.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If environmental control methods are used to prevent allergens, then individuals can reduce exposure to allergens, but these methods cannot completely block allergens from contacting the human body
Solution Approach 1:
The recombinant lactic acid bacterium acts as an intermediary substance that mediates between the allergen and the human body. When administered, it induces antibody production that interferes with the allergen's ability to trigger allergic reactions, providing reliable protection while allowing environmental control measures to continue
Solution Approach 2:
The patent extracts the essential protective function from environmental control and encapsulates it in the recombinant bacterium. By isolating the allergen proteins and using them to induce specific antibody responses, the system separates the protective mechanism from the environmental factors, enabling active immunoprotection
2Object-affected harmful factors
If environmental control is implemented to reduce allergen breeding, then physical discomfort from allergies can be reduced, but severe allergic reactions may still occur
Solution Approach 1:
The recombinant lactic acid bacterium performs preliminary anti-action by inducing antibody production before allergen exposure occurs. These pre-formed antibodies are ready to neutralize allergens upon contact, preventing severe reactions before they can develop, thereby guaranteeing safety
Solution Approach 2:
The system performs preliminary action by pre-inducing the immune system to produce protective antibodies through the recombinant bacterium. This advance immunization ensures that when allergens are encountered, the body already has the defensive mechanisms needed to prevent severe reactions
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The recombinant lactic acid bacterium effectively prevents and treats allergic diseases by inducing antibodies against dust mite and cockroach allergens, reducing symptoms like asthma and atopic dermatitis, comparable to clinical steroid treatment.
Implementation Method 1
the recombinant lactic acid bacterium is capable of expressing a protein with amino acid sequence coded as SEQ ID No: 2
Implementation Method 2
the recombinant lactic acid bacterium is capable of inducing an individual to produce antibodies against cockroach and/or dust mite allergens
Data Source
AI summary
A recombinant lactic acid bacterium and a method thereof for simultaneous treatment and/or prevention of dust mite and cockroach allergies. The recombinant lactic acid bacterium has a gene fragment with nucleotide coded as SEQ ID No: 1 to be capable of expressing the D2P2 protein with amino acid sequence of SEQ ID No: 2. Therefore, by administering an effective amount of the recombinant lactic acid bacterium to an individual is capable of effectively causing the individual's body to produce antibodies against dust mite and/or cockroach allergens, thereby achieving an efficacy of preventing and/or treating an allergic disease caused by dust mite and/or cockroach allergens.