Mass Spectrometry Sample Support with Position Markers

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Solution Overview

Problem

In mass spectrometry, it is challenging to recognize the irradiation range of an energy ray due to the narrow visual field of cameras attached to the mass spectrometry device, making it difficult to determine the exact area being irradiated.

Innovation Solution

A sample support with a substrate having through holes and a conductive layer, along with a frame body that surrounds the ionization region and includes markers for recognizing the position, allows for easy recognition of the irradiation range by scanning these markers using a camera.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Device complexity

If a narrow visual field camera is used in the mass spectrometry device, then the device complexity is reduced, but the ability to recognize the irradiation range deteriorates

Engineering Contradiction:
Improvedevice complexityVSAvoiddifficulty of recognizing irradiation range
Core Design Contradiction:
Device complexityVSDifficulty of detecting and measuring

Solution Approach 1:

The patent introduces markers as an intermediary element that mediates between the camera's limited visual field and the need to recognize the irradiation range. The markers are placed on the sample support at positions corresponding to the irradiation range, allowing the camera to detect these markers and thereby identify the irradiation area without needing a wide visual field. This intermediary solution resolves the contradiction by enabling range recognition through marker detection rather than direct visual observation of the entire irradiation area.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Measurement precision

If the entire sample support is observed to recognize the irradiation range, then the recognition accuracy is improved, but the ease of operation deteriorates due to the need for complex observation procedures

Engineering Contradiction:
Improverecognition accuracy of irradiation rangeVSAvoidease of operation
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The patent applies visual markers that create distinct visual contrasts or color changes to indicate the irradiation range. These markers are designed to be easily distinguishable, allowing operators to quickly identify the irradiation area through simple visual inspection or camera capture. The markers transform the abstract concept of irradiation range into a visually distinct pattern that can be recognized at a glance, thereby improving both recognition accuracy and operational ease without requiring complex observation procedures.

Inventive Principle:
Principle #32Color changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables accurate determination and visualization of the irradiation range, improving the handling and ionization process by facilitating the recognition of the energy ray's impact area, even with limited camera visibility.

Implementation Method 1

energy is transmitted to the component of the sample moved to the first surface side via the conductive layer, and thus, it is possible to ionize the component of the sample

Methodology Applied
Scientific EffectThermal conduction: Conduction (thermal)

Implementation Method 2

it is possible to move the sample (a component of the sample) toward the first surface side from the second surface side through the through hole by using a capillary action

Methodology Applied
Scientific EffectCapillary action: Capillary Action

Data Source

PatentUS11694883B2Sample support, sample ionization method, and mass spectrometry method
Publication Date: 2023.07.04 HAMAMATSU PHOTONICS KK
  • US11694883B2 patent drawing
  • US11694883B2 patent drawing
  • US11694883B2 patent drawing

AI summary

A sample support is a sample support for sample ionization, including: a substrate formed with a plurality of through holes opening to a first surface and a second surface on a side opposite to the first surface; a conductive layer provided not to block the through hole in the first surface; and a frame body provided in a peripheral portion of the substrate to surround an ionization region in which a sample is ionized when viewed in a thickness direction of the substrate, in which a marker for recognizing a position in the ionization region is provided in the frame body.