Seamless Capsule Core Composition for Delayed Disintegration Control
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Solution Overview
Problem
Existing seamless capsule technologies lack the ability to effectively delay disintegration and provide sufficient design freedom, particularly in controlling the release time of active substances, due to limitations in film design and composition.
Innovation Solution
Incorporating an amphoteric surfactant, such as lecithin, into the core of the capsule, combined with fats having a melting point of 40°C or more, and using a water-soluble natural polymer in the outermost layer, along with intermediate layers of fats with a melting point of 45°C or more, to control disintegration time and enhance design flexibility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If existing film improvement techniques are used to delay disintegration, then disintegration delay is achieved, but the degree of freedom in film design is reduced
Solution Approach 1:
The patent extracts the disintegration delay function from the film layer and relocates it to the core composition. By placing an amphoteric surfactant and fat having a melting point of 40°C or more in the core, the capsule achieves delayed disintegration without relying on complex film design, thereby maintaining film design freedom while achieving the desired delay effect
Solution Approach 2:
The patent changes the physical and chemical parameters of the core by incorporating specific components (amphoteric surfactant and high melting point fat). This compositional parameter change enables the core itself to control disintegration timing through temperature-dependent melting behavior, independent of film composition adjustments
2Productivity
If conventional seamless capsule structures are used, then production simplicity is maintained, but control over release time of active substances is insufficient
Solution Approach 1:
The patent utilizes the melting point parameter of fats (40°C or more) to control release timing. The amphoteric surfactant and fat combination in the core creates a temperature-responsive system that melts at body temperature, enabling controlled release of active substances without requiring complex multi-layer structures or additional control mechanisms
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method allows for delayed disintegration of the capsule, independent of pH changes in the gastrointestinal tract, enabling targeted release of active substances at specific intestinal regions, thereby enhancing the effectiveness and control of drug delivery.
Implementation Method 1
the core contains an active substance, an amphoteric surfactant, and a fat having a melting point of 40° C. or more
Implementation Method 2
the outermost layer contains a water-soluble natural polymer
Data Source
AI summary
An object of the present invention is to provide a technique for delaying disintegration of a capsule by blending a certain component in a core of the capsule, and to increase the degree of freedom in capsule design. The present invention relates to a delayed disintegration-type seamless capsule that is a seamless capsule including a core, one or more intermediate layers formed on the core, and an outermost layer formed on the intermediate layers, wherein the core contains an active substance, an amphoteric surfactant, and a fat having a melting point of 40° C. or more, at least one layer of the intermediate layers contains a fat having a melting point of 45° C. or more, and the outermost layer contains a water-soluble natural polymer. The present invention also relates to a method for producing the same.