Segmented Detector Array for Targeted Mass Spectrometry

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Solution Overview

Problem

The high cost and complexity of ion array detectors in distance-of-flight mass spectrometry (DOF MS) systems hinder their adoption, particularly due to the tradeoff between detector density and detection region length, which affects mass resolution and cost, limiting their widespread use.

Innovation Solution

A detector system for targeted analysis (tDOF-MS) is developed, incorporating a mix of active detector/collector elements and inactive 'dummy' elements, allowing for focused detection and collection of specific m/z values of interest, reducing the need for extensive detector arrays and optimizing resource utilization.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If the width of detector elements is reduced to match the dispersion of ions of a single m/z for maximum mass resolution, then mass resolution is improved, but the cost of the detector system increases more than proportionally to the number of detectors per cm

Engineering Contradiction:
Improvemass resolutionVSAvoiddetector system cost
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The detector array is segmented into active detector elements and inactive dummy elements. Only the active elements are connected to readout circuits, while dummy elements are simple conductive structures without expensive electronics. This segmentation allows the physical detector region to be extended without proportionally increasing the number of expensive readout circuits, thereby reducing the cost per unit length while maintaining the necessary detector element width for high mass resolution.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The dummy elements serve multiple functions: they maintain the physical continuity and geometric structure of the detector array, provide electrical grounding and field uniformity, and enable the use of simpler, less expensive readout circuitry compared to fully active detector elements. This multi-functionality allows the system to achieve high mass resolution without the prohibitive cost of having every detector element fully active with its own readout circuit.

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Adaptability or versatility

If the length of the detection region is increased to maximize the range of m/z values detected, then the range of m/z detected is improved, but the detector density needs to be reduced which increases the cost

Engineering Contradiction:
Improverange of m/z detectedVSAvoiddetector cost
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The detection region is divided into active detector elements interspersed with inactive dummy elements. This segmentation allows the overall detection region length to be extended to accommodate a wider range of m/z values, while the inactive dummy elements reduce the proportion of expensive active detector elements and readout circuits needed, thereby lowering the overall cost while maintaining extended m/z range capability.

Inventive Principle:
Principle #1Segmentation

3Adaptability or versatility

If a full array of detectors is used to detect all m/z values, then the versatility of the system is improved, but the cost and complexity increase more than proportionally

Engineering Contradiction:
Improvedetection capabilityVSAvoiddetector array cost
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The detector array is segmented into active detector elements connected to readout circuits and inactive dummy elements that are not connected to expensive readout electronics. This segmentation enables the system to maintain versatility by having sufficient active elements to detect various m/z values while dramatically reducing the overall cost and complexity by replacing many potential active elements with simpler dummy elements.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Instead of implementing a full array of expensive active detector elements with readout circuits across the entire detection region, the system uses partial action by deploying only the minimum necessary active detector elements to achieve the required detection capability, with the remainder being simpler dummy elements. This partial implementation achieves the necessary versatility at a fraction of the cost of a complete active array.

Inventive Principle:
Principle #16Partial or excessive action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach enables efficient targeted analysis with reduced hardware costs, increased dynamic range, and improved detection capabilities, allowing for the separation and collection of specific molecules without increasing detector complexity or cost, surpassing limitations of traditional TOF and quadrupole-based systems.

Implementation Method 1

The ion mirror 4 has a linear retarding field that turns the ions around forming a ribbon shaped beam 8

Methodology Applied
Scientific EffectIon reflection in electric field: Electric Field

Implementation Method 2

At a specific time, called the energy focus time, a voltage 12 is applied to the push plate 9 to drive the ions to the detector element corresponding to each ion's position

Methodology Applied
Scientific EffectIon acceleration by electric field: Electric Field

Data Source

PatentUS11127580B2Detector system for targeted analysis by distance-of-flight mass spectrometry
Publication Date: 2021.09.21 UNM RAINFOREST INNOVATIONS
  • US11127580B2 patent drawing
  • US11127580B2 patent drawing
  • US11127580B2 patent drawing

AI summary

A detector system for targeted analysis and/or sample collection by distance-of-flight mass spectrometry (tDOF-MS).