Senolytic Dietary Supplement Composition for Managing Senescent Cells
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Solution Overview
Problem
There is an unmet need for safe and effective botanical dietary supplements that can manage senescent cells to improve mental function and physical performance during aging, as existing solutions fail to address the heterogeneity of senescent cells across different tissues and their diverse survival mechanisms.
Innovation Solution
A dietary supplement composition combining plant extracts like Rhus succedanea Stem Extract standardized for Fisetin, Piper longum Root Extract for Piperlongumine, and Sophora japonica L. Flower Extract for Quercetin, administered intermittently to target multiple senescent cell anti-apoptotic pathways, promoting improved cognitive and physical performance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a single botanically-derived supplement is used, then safety is improved, but effectiveness against heterogeneous senescent cells deteriorates
Solution Approach 1:
The patent combines multiple botanically-derived compounds (fisetin, quercetin, piperlongumine, curcumin, resveratrol, genistein) into a single dietary supplement formulation. This merging approach maintains safety through natural origins while achieving versatility by targeting multiple senescent cell subpopulations through different mechanisms of action, thereby resolving the contradiction between safety and effectiveness against heterogeneous senescent cells.
Solution Approach 2:
The dietary supplement is designed with multi-functionality to address diverse senescent cell anti-apoptotic pathways simultaneously. Each compound in the formulation targets specific pathways (e.g., fisetin targets Bcl-2, quercetin targets PI3K/AKT, piperlongumine targets Bcl-xL), making the single supplement universally effective against various types of senescent cells while maintaining botanical safety.
2Productivity
If continuous dosing is used, then effectiveness in eliminating senescent cells is improved, but safety deteriorates due to potential toxicity
Solution Approach 1:
The patent implements periodic (intermittent) dosing schedules rather than continuous administration. This allows effective accumulation of senolytic compounds during treatment periods to eliminate senescent cells, followed by pause periods that enable clearance of compounds and reduction of potential toxicity, thereby resolving the contradiction between productivity and safety.
Solution Approach 2:
The supplement formulation includes compounds that preferentially accumulate in senescent cells before administration, and the intermittent dosing allows preliminary elimination of senescent cells followed by recovery periods, preventing toxicity buildup while maintaining effectiveness over time.
Data Source
AI summary
A composition and method for improving mental function and physical performance with aging is disclosed. The composition comprises Rhus succedanea stem extract standardized for Fisetin, Piper longum root extract standardized for Piperlongumine, and Sophora japonica L. flower extract standardized for Quercetin. The composition may optionally include Sophora japonica L. flower extract standardized for Luteolin, Curcuma longa root standardized for curcuminoids, Olive Leaf extract standardized for olive polyphenols, milk thistle seed extract standardized for silymarin, soybean seed extract standardized for soy isoflavones, and Senactive® senolytic or combinations thereof. The composition is formulated for oral administration and may be taken intermittently for a couple to a few days at a time, followed by a week to several weeks without supplementation, with this dosing regimen repeated.