Settable Bone Hemostatic Composition With Reduced Brittleness
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing bone cements, pastes, and putties exhibit undesirable properties such as brittleness, limiting their clinical effectiveness in bone hemostasis, repair, and reconstruction.
Innovation Solution
Reactive compositions that can be mixed to form a settable and moldable material which cures into a hardened form, comprising reagents that react to form a final, hardened form, and can be absorbable or nonabsorbable, suitable for bone hemostasis, repair, and reconstruction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing bone cements, pastes, and putties are used, then bone hemostasis, repair, and reconstruction can be achieved, but the materials exhibit brittleness which limits clinical effectiveness
Solution Approach 1:
The patent changes the material parameters by incorporating polymers with specific glass transition temperatures (Tg) between -50°C to 100°C and controlled molecular weights (10,000 to 1,000,000 g/mol). This parameter modification transforms the material from brittle to ductile while maintaining bone repair functionality, directly resolving the contradiction between clinical effectiveness and brittleness.
Solution Approach 2:
The invention creates a composite material system combining polymers (with specific Tg and molecular weight ranges) with bone cement components. This composite approach integrates the ductility of polymers with the bone repair properties of calcium phosphate/sulfate and magnesium-based cements, eliminating brittleness while preserving clinical effectiveness.
2Ease of operation
If reactive compositions are mixed to form a settable and moldable material, then the material becomes suitable for bone manipulation and reconstruction, but the composition undergoes chemical reaction and curing
Solution Approach 1:
The patent divides the bone cement system into separate reactive compositions (e.g., calcium phosphate/sulfate-based and magnesium-based components) that are mixed only at the point of use. This segmentation allows the material to remain stable during storage while enabling settable and moldable properties when mixed, simplifying the overall system by avoiding complex pre-reaction processes.
Solution Approach 2:
The reactive compositions are prepared in advance in a stable, unmixed state with controlled reactivity. The chemical reactions are designed to occur only after mixing with specific triggers or conditions during surgery, allowing the material to be stored and transported easily while providing settable and moldable properties when needed, thus reducing operational complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The reactive compositions provide improved clinical effectiveness by offering a settable and moldable material that secures bone fragments and allows for hardware insertion without drills, with properties that resist irrigation and bodily absorption, suitable for immediate bone manipulation and reconstruction.
Implementation Method 1
reactive compositions which can be mixed together to produce a composition which cures into a final, hardened form
Data Source
AI summary
Provided herein are settable bone hemostatic and adhesive compositions for use in surgical procedures comprising a variety of disclosed particles. Also provided are related compositions, including surgical kits and packages, as well as methods of making and using the compositions.