Streptococcus CECT 9174 Strain for Oral Microbiome Balance
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Solution Overview
Problem
Current treatments for oral infections such as caries and periodontal disease using antibiotics disrupt the oral microbiome, leading to undesired microbial imbalances, and there is a need for an antimicrobial agent that can effectively adhere to dental surfaces to compete with pathogenic bacteria like S. mutans, A. naeslundii, V. parvula, and A. actinomycetemcomitans.
Innovation Solution
A novel Streptococcus bacterial strain (CECT 9174) is identified, which is deposited at the Colección Española de Cultivos Tipo, capable of secreting antimicrobial substances that inhibit the growth of S. mutans and other periodontal pathogens, and can be used in compositions for prophylactic or therapeutic treatments, or as a probiotic to improve oral health.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If antibiotics are used to treat caries and periodontal disease, then the harmful bacteria are eliminated, but the useful bacteria in the oral cavity are also destroyed, leading to microbial imbalances
Solution Approach 1:
The patent uses bacteriocins as intermediary substances produced by beneficial oral bacteria to selectively target and eliminate pathogenic bacteria. These bacteriocins act as mediators that specifically inhibit harmful microorganisms while preserving the beneficial oral microbiome, thus resolving the contradiction between eliminating pathogens and maintaining microbial balance
Solution Approach 2:
The patent converts the harmful effect of bacterial competition into a beneficial therapeutic effect. Beneficial bacteria naturally produce bacteriocins as part of their competitive strategy to outcompete pathogenic bacteria. This natural competitive mechanism is harnessed therapeutically to eliminate pathogens while maintaining the beneficial bacteria that produce the bacteriocins, turning the harmful competitive interaction into a beneficial treatment
2Object-affected harmful factors
If S. salivarius strains are used to produce bacteriocins against mutans streptococci, then antimicrobial activity is achieved, but the strains are virtually absent from dental surfaces and cannot effectively compete with pathogenic bacteria at the tooth surface
Solution Approach 1:
The patent identifies and selects bacterial strains with specific phenotypic parameters that enable dental surface adherence. The novel Streptococcus strains possess specific surface properties, adhesion molecules, and ecological characteristics that allow them to colonize dental surfaces effectively, changing the parameter of strain selection from general bacteriocin production to specific adherence capability combined with bacteriocin production
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The bacterial strain effectively inhibits the growth of S. mutans and other periodontal pathogens, preventing and treating oral infections by maintaining a healthy oral microbiome, and can be administered in various forms such as toothpaste, mouthwash, or dietary supplements.
Implementation Method 1
capable of secreting antimicrobial substances that inhibit the growth of S. mutans and other periodontal pathogens
Data Source
AI summary
The present invention belongs to the field of the biotechnology, and relates to novel Streptococcusbacteria which are useful as antimicrobial agents, particularly against caries and periodontal disease. The invention relates to compositions and functional food comprising the novel bacteria. In particular, the present invention relates to a novel bacterial strain, deposited at the Colección Española de Cultivos Tipo, with accession number CECT 9174, which has proven to be useful in the prevention and treatment of caries and periodontal disease.