Mesenchymal Stromal Cell Therapy for Faster Return to Estrus

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Solution Overview

Problem

Existing methods to reduce the number of days required for return to estrus in animals, such as breeding sows, are limited, particularly due to restrictions on hormone administration and inefficiencies in feed changes, necessitating a more effective approach.

Innovation Solution

Administering mesenchymal stromal cells, specifically adipose-derived stem cells, to animals to promote the resumption of estrus, reducing the time needed for return to estrus.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If feed changes or improvements are made to reduce the number of days required for return to estrus, then reproductive efficiency is improved, but the effectiveness is limited and cannot significantly reduce the return to estrus period

Engineering Contradiction:

Improvereproductive efficiencyVSAvoidnumber of days required for return to estrus

Core Design Contradiction:

ProductivityVSLoss of time

Solution Approach 1:

The invention changes the fundamental parameter from nutritional management to cellular therapy by administering mesenchymal stromal cells. This cellular intervention directly addresses the physiological barriers to return to estrus, achieving a significant reduction from 30-50 days to approximately 10-15 days, thereby resolving the limitation of feed-based approaches.

Inventive Principle:

Principle #35Parameter changes

2Loss of time

If hormones are administered to reduce the number of days required for return to estrus, then the return to estrus period is shortened, but hormone administration is prohibited in some countries

Engineering Contradiction:

Improvenumber of days required for return to estrusVSAvoidapplicability across different regions

Core Design Contradiction:

Loss of timeVSAdaptability or versatility

Solution Approach 1:

The invention uses mesenchymal stromal cells as an intermediary substance to achieve the desired physiological effect without using prohibited hormones. These cells act as a mediator that regulates the return to estrus through natural cellular mechanisms, making the treatment applicable globally without regulatory restrictions.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Productivity

If the postpartum period is extended to allow natural return to estrus, then animal welfare is maintained, but reproductive efficiency is reduced

Engineering Contradiction:

Improvereproductive efficiencyVSAvoidduration of postpartum period

Core Design Contradiction:

ProductivityVSDuration of action of moving object

Solution Approach 1:

The invention applies preliminary action by administering mesenchymal stromal cells during the postpartum period to actively promote and accelerate the return to estrus. This proactive cellular therapy prevents the natural delay in estrus resumption, thereby shortening the postpartum interval and improving reproductive turnover without compromising animal welfare.

Inventive Principle:

Principle #10Preliminary action

Data Source

PatentUS20260053860A1Method of promoting return of estrus in animal and agent for promoting return to estrus in animal

Publication Date: 2026.02.26 ANICOM HOLD INC

AI summary

A method of promoting return to estrus in an animal and an agent for promoting return to estrus in an animal are provided. The method is a method of promoting return to estrus in an animal, characterized by including a step of administering mesenchymal stromal cells or a composition containing mesenchymal stromal cells to the animal. The mesenchymal stromal cells are preferably adipose-derived stem cells, and the animal is preferably a farm animal, a dog, or a cat.