Sustained Releasing Particle Core-Shell Structure
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Solution Overview
Problem
Sustained releasing particles with water-soluble physiologically active substances often experience an initial burst due to uneven distribution of the active substance, leading to adverse effects and poor control over the administration cycle.
Innovation Solution
The development of sustained releasing particles with a fat-soluble base material and a surface area to volume ratio of 0.6 or less, produced using a method involving the discharge of a liquid droplet containing the active substance and solvent, followed by solvent removal with a dry gas stream where the dew point temperature difference is 20 degrees Celsius or less.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If a fat-soluble base material is used to dissolve water-soluble physiologically active substance, then the dissolution stability and duration are improved, but the water-soluble physiologically active substance becomes unevenly distributed at the outer side of the particle, causing initial burst
Solution Approach 1:
The patent applies local quality by creating a core-shell structure where the inner core contains the water-soluble physiologically active substance and the outer shell is formed from fat-soluble base material. This spatial differentiation allows the active substance to be protected from initial burst while maintaining controlled dissolution over time. The core region provides uniform distribution of water-soluble substance, while the shell provides sustained release characteristics.
2Speed
If the surface area to volume ratio is increased, then the dissolution rate is improved, but the initial burst effect is enhanced due to higher concentration of water-soluble substance at the particle surface
Solution Approach 1:
The patent segments the particle into distinct functional regions: an inner core containing the water-soluble physiologically active substance and an outer shell made of fat-soluble base material. This segmentation prevents the water-soluble substance from concentrating at the surface, thereby reducing initial burst while maintaining controlled dissolution rate through the shell structure.
Solution Approach 2:
The patent uses composite materials by combining water-soluble physiologically active substance with fat-soluble base material in a core-shell configuration. This composite structure leverages the complementary properties of both materials: the water-soluble core provides the active substance with uniform distribution, while the fat-soluble shell provides sustained release and prevents surface concentration, thereby controlling the dissolution rate and preventing initial burst.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach prevents initial bursts and ensures excellent sustained releasing properties, maintaining a consistent release of the physiologically active substance over time, reducing adverse effects and improving control over the administration cycle.
Implementation Method 1
removing the solvent from the liquid droplet by a dry gas stream
Data Source
AI summary
A sustained releasing particle contains a water-soluble physiologically active substance and a fat-soluble base material, wherein the sustained releasing particle has a ratio of a surface area to a volume is 0.6 or less.