Pharmaceutical Non-Active Ingredients TRIZ Cases

Four-branch H-shaped PEG structure boosts drug loading capacity while degradable linkages reduce toxic side effects.

A transdermal patch uses a self-crosslinking acrylic copolymer matrix to deliver nitroglycerin.

A biodegradable polyethylene glycol derivative uses a cyclic benzylidene acetal linker to divide into low molecular weight chains.

Anti-HER2 immunoconjugates link antibodies to benzazepine adjuvants, enabling effective treatment of inaccessible tumors.

Core-shell particle with fat-soluble shell prevents initial burst of water-soluble active substance.

A bimodal acemetacin formulation combines micronized immediate-release granules with non-micronized retard-release units to deliver dual-phase drug delivery.

Modular linker compounds use cleavable peptide sequences and self-immolative spacers to enable homogeneous drug loading on antibody-drug conjugates.

Acidifying topcoat lowers local pH at the coating interface, preventing premature dissolution of enteric polymers in acidic environments.

Hydroxyalkyl cellulose and polyethylene oxide polymers reduce surface tension to suppress aerosol formation during dental irrigation.

Modular membrane cloaking enables systemic extracellular vesicle delivery, resolving specificity limits of local injection methods.

Polymeric dual drugs use spacing groups and chromophore moieties as covalent linkers to attach therapeutic agents.

A biodegradable hydrogel uses a cyclic benzylidene acetal structure to enable precise crosslinking and controlled degradation kinetics.

An isotonic lipid emulsion with 10-250 nm particles rapidly absorbs Omega-3 fatty acids into cell membranes.

An aqueous wound healing formulation creates a breathable polymeric film that adheres to skin without stinging.

Polyethylene glycol spacers in biotinylated conjugates allow controlled cell release via biotin competition, preserving viability.

Antithrombotic nanoparticles retain high affinity coagulation inhibitors on their exterior surface to delay thrombus formation.

Siloxane derivatives of amino acids lower critical micelle concentration to improve active ingredient solubility and stability in healthcare products.

Squalene and phospholipid nanoemulsions solve low loading concentration limits for amphiphilic immunopotentiators.

Low ionic strength complexation yields homogeneous protamine-RNA nanoparticles that modulate immune response by enhancing IFN-alpha while reducing TNF-alpha.

Replacing ester bonds with stable amide linkages in PEG hydrogels eliminates lag phases and burst releases for efficient drug delivery.

Light-initiated crosslinking eliminates acid or heat requirements, expanding solvent compatibility for polyrotaxane materials.

Direct compression of a polyvinyl alcohol resin with a specific plasticizer content balances mechanical strength against rapid disintegration time.

Plectin-targeted liposomes reduce tumor volume and side effects by delivering PARP inhibitors specifically to cancer cells.

Acid-hydrolyzed alginates form non-uniform barriers that resolve manufacturing precision trade-offs while improving absorption efficiency.

Controlling the viscosity ratio of polyalkylene oxide particles reduces drug dissolution variation during transfer.

A force-dependent DNA tension sensor releases chemotherapeutic agents only when cancer cells exert threshold mechanical forces.

A dissolvable polymeric film with mucoadhesive properties covers the cornea to provide sustained lubrication and hydration during ophthalmic procedures.

A dual-layer enteric coating uses selective polymer neutralization to trigger rapid disintegration upon intestinal entry.

Hydrotrope molecules form hydrogen bonds with water to create a stable outer shell around hydrophobic cores, eliminating the need for surfactants or polymers.

Applying isothiocyanate functional surfactants reduces psoriasis symptoms without the drawbacks of existing treatments.

Water-in-oil microemulsions enable nanoparticle formation from aqueous polymers without organic solvents, improving drug bioavailability.

A unimodal polyether composition with Mw/Mn 1.20 or less modifies bulk drugs to ensure formulation stability.

Metal salts of aromatic sulfonates accelerate aliphatic polyester resin crystallization for faster molding.

Semicarbazide reacts with ortho-acyl phenylboronic acid to form a stable diazaborine ring, enabling selective polypeptide conjugation without harsh conditions.

Montelukast topical emulsion and gel formulations stabilize the drug via pH control and low water content, improving skin permeation.

Synthesizing active carbonate esters from water-soluble polymers using excess activated reagents and reactive molecule consumption.

Spermine-decorated microbubbles bind nucleic acids via electrostatic interactions, overcoming weak binding and toxicity limits of viral vectors.

Fluidized bed granulation creates starch granules that provide oral disintegratability and hardness without auxiliary excipients.

Silk fibroin films grafted with brush-like polymers via atom transfer radical polymerization enhance surface hydrophilicity and functionalization.

An enteric core/shell polymer coating prevents unintended active ingredient release in the stomach due to ethanol while ensuring rapid intestinal dissolution.

Lipid nanocapsules protect creatine fatty esters from plasma degradation while enabling rapid brain accumulation to treat transporter deficiency.

Oppositely charged block copolymers self-assemble into stable vesicles without organic solvents, enabling reliable drug encapsulation.

Branched star polymers display ligands to control hydrodynamic radius, reducing non-specific tissue interactions while maintaining particle stability.

An enteric-coated nano-silica yeast particle delivery system resists digestive degradation to enable stable oral drug transport.

A biocompatible core/shell composition encapsulates mRNA within a polymer core and lipid shell for targeted delivery to antigen-presenting cells.

Isomalt and microcrystalline cellulose mixtures enable controlled active ingredient release independent of osmolality.

Divalent ursolic acid salts overcome poor water solubility and low bioavailability by forming divalent structures that enhance dissolution rates.

AR degraders combine with targeted drugs to inhibit triple-negative breast cancer cell proliferation.

Step-wise salt introduction into swelled oxidized cellulose minimizes degradation while preserving high oxidation levels.