Synergistic Herbal Composition for Liver Health via NADPH Oxidase Inhibition
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current treatments for liver health issues, such as viral hepatitis, cirrhosis, and drug-induced liver damage, often have side effects and rely on antibiotics, which are becoming less effective due to resistance, necessitating a safer and more effective herbal alternative for both humans and animals.
Innovation Solution
A synergistic composition combining extracts from Sphaeranthus indicus and Terminalia chebula, potentially with additional herbs like Curcuma longa, is developed to inhibit NADPH oxidase activity and enhance glutathione levels, offering hepatoprotective effects and reducing liver enzyme levels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments for liver health issues are used, then liver damage can be treated, but side effects occur and antibiotic resistance develops
Solution Approach 1:
The patent changes the fundamental parameter of treatment approach by transitioning from conventional pharmaceutical/antibiotic treatments to a herbal-based treatment system. Specifically, it combines extracts from Terminalia chebula (containing chebulagic acid, chebulinic acid, ellagic acid, and gallic acid) with Sphaeranthus indicus (containing 7-hydroxyfrullanolide) to create a new treatment paradigm that achieves hepatoprotective effects without the harmful side effects and resistance issues associated with conventional treatments
Solution Approach 2:
The patent creates a composite herbal formulation by combining extracts from multiple plant sources (Terminalia chebula and Sphaeranthus indicus) into a synergistic preparation. This composite approach integrates the hepatoprotective properties of chebulagic acid, chebulinic acid, ellagic acid, gallic acid from T. chebula with the active compounds from S. indicus, producing a treatment that is more effective and safer than single-herb or conventional treatments alone
2Object-affected harmful factors
If herbal alternatives are developed, then safety and effectiveness can be improved, but treatment complexity increases
Solution Approach 1:
The patent merges multiple herbal extracts into a single integrated formulation, combining Terminalia chebula extract (rich in chebulagic acid, chebulinic acid, ellagic acid, and gallic acid) with Sphaeranthus indicus extract (containing 7-hydroxyfrullanolide). This consolidation creates a unified hepatoprotective treatment that simplifies administration while maintaining the synergistic benefits of multiple active compounds, thereby improving safety without excessively increasing treatment complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition demonstrates significant inhibition of NADPH oxidase and elevation of glutathione, effectively reducing liver enzyme levels and improving liver health, with applications in both human and animal treatments, including aquaculture, while minimizing side effects.
Implementation Method 1
The composition demonstrates significant inhibition of NADPH oxidase
Implementation Method 2
elevation of glutathione
Data Source
AI summary
The invention discloses synergistic compositions comprising at least one component selected from extract(s) and fraction(s) or mixtures thereof derived from Sphaeranthus indicus in combination with at least one component selected from extract(s), fraction(s), active compound(s) or mixtures thereof derived from Terminalia chebula for improving the liver health. The invention further discloses method of improving the liver health in humans and animals by administering the compositions comprising at least one component selected from extract(s) and fraction(s) or mixtures thereof derived from Sphaeranthus indicus in combination with at least one component selected from extract(s), fraction(s), active compound(s) or mixtures thereof derived from Terminalia chebula.