Transdermal Patch Positioning Frame with Skin Penetration Tool
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Solution Overview
Problem
The transfer of active substances from transdermal therapeutic systems is impeded by the barrier properties of the skin, and existing methods require the simultaneous use of hollow needles and therapeutic agents.
Innovation Solution
A device with a positioning frame and a tool unit that creates openings in the uppermost skin layer, allowing the transdermal therapeutic system to be immersed in a recess after the tool unit is removed, enabling diffusion channels in the skin for effective active substance delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hollow needles are used to transport therapeutic agents through the skin, then drug delivery is achieved, but the device complexity increases and requires simultaneous use of needles and therapeutic agents
Solution Approach 1:
The patent separates the needle function from the therapeutic agent application. The needle unit is used only to create perforations in the skin, while the therapeutic agent is applied separately through the created openings. This extraction of functions simplifies the overall device by eliminating the need for complex needle-therapeutic agent integration systems.
Solution Approach 2:
The device is divided into separate functional components: a needle unit for creating perforations and a separate therapeutic agent application system. The needle unit can be removed after creating the perforations, leaving only the simple therapeutic agent application component on the skin. This segmentation reduces device complexity while maintaining reliable drug delivery.
2Object-affected harmful factors
If the stratum corneum remains intact, then skin barrier protection is maintained, but active substance transfer is impeded
Solution Approach 1:
The needle unit creates perforations through the stratum corneum before applying the therapeutic agent. This preliminary action opens diffusion channels in advance, allowing the subsequently applied therapeutic agent to penetrate the skin effectively without requiring continuous presence of needles or complex delivery mechanisms.
Solution Approach 2:
The needle-created perforations serve as intermediaries that facilitate the transfer of therapeutic agents through the skin barrier. Instead of directly forcing agents through intact skin or using complex needle-based delivery, the perforations act as simple pathways that enable efficient passive diffusion of the therapeutic agent.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution enhances the transfer of active substances through the skin, facilitating effective subcutaneous drug delivery by creating diffusion channels in the skin layer, thereby improving the delivery efficiency of transdermal therapeutic systems.
Implementation Method 1
a tool unit (40) that can be inserted into and centered within the recess (21) of the positioning frame (20) for creating perforations at least in the uppermost layer of the skin
Implementation Method 2
enabling diffusion channels in the skin for effective active substance delivery
Data Source
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AI summary
The invention relates to a device with a positioning frame which can be adhered onto the skin and with a transdermal therapeutic system which can be inserted into a cut-out that passes through the positioning frame, the active substance-dispensing outlet side of the inserted transdermal therapeutic system facing the skin. The device comprises a tool unit which can be inserted into the cut-out of the positioning frame and centered in said cut-out in order to produce openings at least in the uppermost layer of the skin. By means of the invention, the active substance transfer of the transdermal therapeutic system is improved.