Turmeric-Ginger-Starch Compacts for Direct Compression
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Solution Overview
Problem
Existing solid dosage forms, such as tablets and capsules, face challenges in compressibility due to poor fluidity and compressibility of active pharmaceutical ingredients, necessitating costly and complex production methods, and natural constituents like turmeric and ginger lack binding capacity for direct compression.
Innovation Solution
A compact composition comprising turmeric, ginger, and starch in dried powdered form, which functions as a binder, lubricant, and disintegrant, allowing for direct compression without additional additives, and can be formulated into tablets or granules.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If direct compression method is used for tablet production, then production speed increases and water-soluble drugs are protected from hydrolysis, but the process fails for most substances due to poor fluidity and compressibility
Solution Approach 1:
The patent applies parameter changes by modifying the physical state of the active ingredient from solid powder to granulated form, and adjusting moisture content and particle size distribution. These parameter modifications improve fluidity and compressibility, enabling direct compression to work for a broader range of substances while maintaining high production speed and preventing hydrolysis.
Solution Approach 2:
The patent introduces granulation as an intermediary step between powder preparation and tablet compression. This intermediary process creates granules that serve as a bridge, improving the flow and compressibility characteristics of the material without requiring additional binders or lubricants, thus enabling reliable direct compression for more substances.
2Ease of manufacture
If granulation is performed to improve fluidity and compressibility, then direct compression becomes feasible, but production complexity and cost increase
Solution Approach 1:
The patent applies self-service by using the active ingredient itself as the binding agent. The granulated active ingredient provides both the structural framework and the binding function, eliminating the need for separate binders, lubricants, or other auxiliary substances. This self-service approach simplifies the formulation process while maintaining direct compression feasibility.
Solution Approach 2:
The patent demonstrates multi-functionality by designing a system where the granulated active ingredient performs multiple functions simultaneously: it serves as the structural matrix, the binding agent, the filler, and the disintegrant. This universal approach reduces the number of components needed and simplifies the production process while enabling direct compression.
3Ease of manufacture
If additional binders and lubricants are added to improve compressibility, then tablet formation is achieved, but the natural properties of the active ingredient are compromised and cost increases
Solution Approach 1:
The patent applies self-service by allowing the active ingredient to bind itself through granulation. The granulated form of the active ingredient provides the necessary binding characteristics without requiring external binders, thereby preserving the natural properties and purity of the active ingredient while achieving successful tablet formation through direct compression.
Solution Approach 2:
The patent applies the extraction principle by removing and eliminating unnecessary additives (binders, lubricants, excipients) from the formulation. By taking out these artificial additives, the patent preserves the natural properties of the active ingredient and reduces cost, while still achieving tablet formation through the granulated structure of the active ingredient itself.
4Ease of manufacture
If powders are converted to granules to improve fluidity, then compressibility improves, but the process requires additional steps and time
Solution Approach 1:
The patent applies merging by combining the granulation step with the formulation process itself. Rather than performing granulation as a separate preliminary step, the patent integrates granulation into the mixing and formulation process, simultaneously achieving both formulation and granulation in one operation. This reduces overall processing time while maintaining the compressibility benefits of granulated material.
Data Source
AI summary
Compacts may include: a first layer comprising turmeric, ginger, and/or starch, and may be configured to release constituents in an aqueous environment, optionally having a granule, pellet and/or tablet morphology. Such compacts may have a total mass of no more than 13 g, whereby each layer may gave a total mass of no more than 13 g. Such compacts may have a hardness above 3 kg and/or a friability of 0.0001 to 7′%. The layers may be positioned at a 0 to 90° angle relative to the pressing direction. Such compacts may have a thickness in a range of from 0.0001 to 12 cm, whereby each layer may have a thickness in a range of from 0.0001 to 12 cm.