UV-Cured Silicone Release Liner for Transdermal Adhesive Removal

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Existing transdermal drug delivery systems face difficulties in removing a release liner from an adhesive layer containing mineral oil without damaging the adhesive or intermediate layer, particularly due to the high mineral oil to polyisobutylene ratio, which requires special manufacturing processes.

Innovation Solution

A transdermal delivery device with a backing layer, adhesive layers containing active pharmaceutical ingredients and mineral oil, and a release liner coated with UV-cured highly crosslinked silicone, allowing for easy peeling without damaging the adhesive layer, even after storage at ambient or elevated temperatures.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a thermally cured release liner is used with a mineral oil containing adhesive layer, then the adhesive layer provides good drug delivery performance, but the release liner cannot be removed without damaging the adhesive layer

Engineering Contradiction:

Improveadhesive layer integrityVSAvoidrelease liner removal

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent changes the curing method parameter from thermal to UV irradiation. The UV-cured silicone coating on the release liner creates a different chemical structure that does not bond with the mineral oil containing adhesive layer, allowing easy removal while maintaining adhesive integrity. This parameter change resolves the contradiction by enabling both reliable adhesive performance and easy release liner removal.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent replaces the thermal curing mechanism with a UV photopolymerization mechanism. Instead of using heat to cure the silicone coating (which creates strong bonds with the adhesive), UV light is used to cure the silicone, creating a different bonding characteristic that allows easy peeling while preserving the adhesive layer.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Productivity

If the mineral oil to polyisobutylene ratio is increased in the adhesive layer, then drug delivery performance is improved, but the difficulty of removing the release liner increases

Engineering Contradiction:

Improvedrug delivery efficiencyVSAvoidmanufacturing process complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The patent replaces thermal curing with UV curing of the release liner coating. This substitution eliminates the need for complex thermal processing equipment and high mineral oil ratios that cause bonding issues, allowing high mineral oil content adhesive formulations to be used without compromising release liner removal capability.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent uses a composite coating system consisting of silicone modified with UV-curable groups applied to the release liner. This composite material provides both the release properties needed for easy removal and the structural integrity required for handling, resolving the contradiction between drug delivery performance and manufacturing complexity.

Inventive Principle:

Principle #40Composite materials

3Ease of operation

If a UV-cured silicone release liner is used, then easy removal is achieved, but the coating thickness must be precisely controlled

Engineering Contradiction:

Improverelease liner peelingVSAvoidcoating thickness control

Core Design Contradiction:

Ease of operationVSManufacturing precision

Solution Approach 1:

The patent specifies a controlled coating thickness range of 2000-10000 angstroms for the UV-cured silicone layer. This parameter control ensures optimal balance between release properties (thinner coating peels easier) and structural integrity (thicker coating provides better protection). The defined range resolves the contradiction by establishing precise manufacturing specifications that achieve both easy peeling and adequate performance.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The UV-cured silicone release liner enables easy removal with minimal force, preserving the integrity of the adhesive layer and simplifying manufacturing processes for multilayered transdermal devices without the need for costly new systems or processes.

Implementation Method 1

a release liner coated with a UV-cured highly crosslinked silicone

Methodology Applied

Scientific EffectUV-curing: Photopolymerisation

Implementation Method 2

UV-cured highly crosslinked silicone

Methodology Applied

Scientific EffectCrosslinking:

Data Source

PatentUS9017301B2Transdermal drug delivery systems comprising a coated release liner

Publication Date: 2015.04.28 MYLAN TECHNOLOGIES INC

AI summary

The present invention refers to a transdermal delivery device comprising a backing layer, at least one adhesive layer, and a release liner coated with a UV-cured highly crosslinked silicone. The present invention also refers to a method of preparing a transdermal delivery device comprising a backing layer, at least one adhesive layer, and a release liner coated with a UV-cured silicone.