Vitamin D-Binding Protein Composition for Telomere Elongation
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Solution Overview
Problem
There is no known biological material that can effectively elongate telomeres to inhibit cellular senescence, which leads to age-related diseases due to telomere shortening and senescent cell-induced inflammation.
Innovation Solution
A senescence inhibitor containing vitamin D-binding protein, preferably treated with β-galactosidase, sialidase, and N-acetylgalactosaminidase, derived from milk or serum, is used to elongate telomeres.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional materials are used to address telomere shortening, then telomere elongation may be achieved, but no biological material has been known to effectively elongate telomeres
Solution Approach 1:
The patent applies parameter changes by treating vitamin D-binding protein with specific enzymes (β-galactosidase, sialidase, and N-acetylgalactosaminidase) to modify its structure and activate its telomere-elongating function. This enzymatic treatment transforms the protein into a form that can effectively elongate telomeres, resolving the contradiction between reliability of telomere elongation and availability of suitable biological materials
2Reliability
If senescent cells are present, then cellular senescence occurs, but senescent cells secrete inflammatory cytokines leading to organ and tissue dysfunction
Solution Approach 1:
The patent applies preliminary anti-action by using the enzyme-treated vitamin D-binding protein to prevent cellular senescence before it occurs. By elongating telomeres and inhibiting senescence, the treatment prevents the subsequent secretion of inflammatory cytokines and the resulting organ and tissue dysfunction, thereby maintaining cellular function without allowing harmful effects to develop
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The senescence inhibitor effectively elongates telomeres, reducing cellular senescence and associated inflammation, with low side effects and potential anti-inflammatory and macrophage-activating properties.
Implementation Method 1
the vitamin D-binding protein is one treated with one or more enzymes selected from the group consisting of β-galactosidase, sialidase, and N-acetylgalactosaminidase
Data Source
AI summary
The present invention aims to provide a senescence inhibitor formed from a material of biological origin. The present invention relates to a senescence inhibitor containing vitamin D-binding protein.