Contactless selection device, light sensing structure thereof, and biological particle selection apparatus

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Solution Overview

Problem

Conventional biological particle selection devices struggle to accurately move target biological particles without physical contact, necessitating improvements for precise path control.

Innovation Solution

A contactless selection device employing a light sensing structure with vertical transistors and alternating current power, utilizing dielectrophoresis forces to manipulate biological particles through non-uniform electric fields generated by emitter pads.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If conventional biological particle selection devices use physical contact methods to move particles, then particle movement control is simple, but particle contamination and path precision are compromised

Engineering Contradiction:
Improveparticle path precisionVSAvoiddevice structure complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent replaces mechanical contact-based particle manipulation with a contactless dielectrophoresis system. Emitter pads generate non-uniform electric fields that exert DEP forces on particles, eliminating physical contact while achieving precise path control. This substitution of mechanical systems with electromagnetic fields resolves the contradiction between contact simplicity and precision.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent introduces an electric field as an intermediary between the device and particles. The emitter pads create non-uniform electric fields that mediate particle movement without direct contact. This intermediary field enables precise control while avoiding contamination issues associated with mechanical contact.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Reliability

If contactless methods are used to move biological particles, then particle contamination is reduced, but path control precision deteriorates

Engineering Contradiction:
Improveparticle contamination controlVSAvoidparticle path precision
Core Design Contradiction:
ReliabilityVSManufacturing precision

Solution Approach 1:

The patent implements local quality by creating non-uniform electric fields through specifically designed emitter pads with varying geometries and configurations. Each region of the device generates tailored electric field distributions to control particle movement in specific areas, enabling precise path control while maintaining contactless operation throughout.

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

The patent employs dynamic control of electric fields through AC power devices that can modulate field strength, frequency, and distribution in real-time. This dynamic adjustment enables precise manipulation of particle trajectories while maintaining contactless operation, resolving the precision issue in contactless methods.

Inventive Principle:
Principle #15Dynamics

3Manufacturing precision

If non-uniform electric fields are generated for dielectrophoresis, then particle manipulation precision is improved, but energy consumption increases

Engineering Contradiction:
Improveparticle positioning precisionVSAvoidenergy consumption
Core Design Contradiction:
Manufacturing precisionVSUse of energy by stationary object

Solution Approach 1:

The patent uses periodic AC signals to generate the non-uniform electric fields required for dielectrophoresis. By employing alternating current at optimized frequencies, the system achieves precise particle positioning while reducing average power consumption compared to continuous DC fields. The periodic nature allows for efficient energy utilization in creating the necessary field gradients.

Inventive Principle:
Principle #19Periodic action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables accurate and contactless movement of biological particles by generating electric fields similar to corona discharge, facilitating precise positioning and capture using a structured emitter pad design.

Implementation Method 1

any one of the vertical transistors of the contactless selection device is configured to be irradiated by a light source so as to allow a plurality of dielectrophoresis (DEP) forces to be applied to move the target biological particle

Methodology Applied
Scientific EffectPhotoelectric effect: Photoelectric Effect

Implementation Method 2

allow a plurality of dielectrophoresis (DEP) forces to be applied to move the target biological particle through a distribution of the emitter pads and an electric field difference that is generated in the liquid specimen from non-uniform electric fields of the emitter pads

Methodology Applied
Scientific EffectDielectrophoresis:

Implementation Method 3

an alternating current (AC) power device... An end of each of the emitter pads away from the first electrode layer is exposed from the insulating layer

Methodology Applied
Scientific EffectElectric field: Electric Field

Data Source

PatentUS12440840B2Contactless selection device, light sensing structure thereof, and biological particle selection apparatus
Publication Date: 2025.10.14 CYTOAURORA BIOTECHNOLOGIES INC
  • US12440840B2 patent drawing
  • US12440840B2 patent drawing
  • US12440840B2 patent drawing

AI summary

A contactless selection device, a light sensing structure thereof, and a biological particle selection apparatus are provided. The light sensing structure includes a substrate, an insulating layer, an electrode layer, and a photoelectric layer, the latter two of which are respectively formed on two opposite sides of the substrate. The photoelectric layer includes a plurality of collector regions, a plurality of base regions respectively formed in the collector regions, and a plurality of emitter regions that are respectively formed in the base regions. Each of the emitter regions includes a plurality of emitter pads formed in the corresponding base region. Each of the base regions, the corresponding collector region, and the corresponding emitter region are jointly formed as a vertical transistor. The insulating layer covers and separates the vertical transistors and an end of each of the emitter pads is exposed from the insulating layer.