Whey Protein Beverage Stability via Hydrolysis and pH Control

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Solution Overview

Problem

Formulating shelf-stable, ready-to-drink whey protein-based nutritional beverages is challenging due to whey protein's susceptibility to heat treatments, which can cause denaturation, aggregation, gelation, and phase separation, making it difficult to achieve high protein content without compromising stability and organoleptic properties, especially at neutral pH suitable for flavors like chocolate and vanilla.

Innovation Solution

A liquid nutritional composition comprising a combination of whey protein hydrolysate and intact whey protein, with a pH of 6.4 to 7.5 and low viscosity, using a weight ratio of 1:4 to 4:1 and incorporating stabilizers like microcrystalline cellulose, carboxymethylcellulose, and carrageenan to maintain stability and acceptable taste and mouthfeel.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If sterilization processes are used to make ready-to-drink protein beverages shelf stable, then shelf stability is improved, but whey protein denaturation and aggregation occur

Engineering Contradiction:
Improveshelf stabilityVSAvoidprotein stability
Core Design Contradiction:
ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent changes the pH parameter to a neutral range (6.5-7.5) and controls the degree of hydrolysis (10-30%) to prevent protein denaturation during sterilization while maintaining shelf stability. This parameter optimization allows the whey protein to withstand heat treatment without aggregating or gelating.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent uses a composite protein system combining intact whey protein with partially hydrolyzed whey protein. This composite structure provides both the functional benefits of intact protein and the stability of hydrolyzed protein, preventing aggregation during sterilization while maintaining shelf stability.

Inventive Principle:
Principle #40Composite materials

2Quantity of substance

If high protein concentration is achieved using whey protein, then nutritional value is improved, but gelation and phase separation occur

Engineering Contradiction:
Improveprotein concentrationVSAvoidbeverage stability
Core Design Contradiction:
Quantity of substanceVSStability of the object's composition

Solution Approach 1:

The patent optimizes the degree of hydrolysis (10-30%) and pH (6.5-7.5) parameters to prevent gelation and phase separation even at high protein concentrations (10-30% w/v). The partial hydrolysis creates smaller peptides that interfere with protein-protein interactions that would otherwise cause gelation.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent creates local structural differences by combining intact whey protein molecules with partially hydrolyzed peptides. This local heterogeneity in the protein structure prevents uniform aggregation and gelation while maintaining high overall protein concentration.

Inventive Principle:
Principle #3Local quality

3Ease of operation

If neutral pH is used for desirable flavors like chocolate and vanilla, then organoleptic properties are improved, but protein stability deteriorates

Engineering Contradiction:
Improveflavor compatibilityVSAvoidprotein stability
Core Design Contradiction:
Ease of operationVSStability of the object's composition

Solution Approach 1:

The patent shifts the pH parameter to a neutral range (6.5-7.5) which is optimal for chocolate and vanilla flavors, while simultaneously controlling the degree of hydrolysis (10-30%) to prevent protein instability. The partial hydrolysis creates a buffer system that maintains protein stability at neutral pH.

Inventive Principle:
Principle #35Parameter changes

4Reliability

If whey protein hydrolysate is used to improve stability, then resistance to heat treatment is improved, but bitterness increases

Engineering Contradiction:
Improveheat resistanceVSAvoidtaste acceptability
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The patent applies partial hydrolysis (10-30% degree of hydrolysis) rather than complete hydrolysis. This partial action provides sufficient heat resistance and stability benefits while minimizing the bitterness that would result from extensive hydrolysis. The intact protein portion masks the bitter taste of hydrolyzed peptides.

Inventive Principle:
Principle #16Partial or excessive action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution allows for a shelf-stable, neutral pH whey protein-based beverage with high protein content, maintaining stability and organoleptic properties, enabling the use of desirable flavors while avoiding issues like gelation and phase separation.

Implementation Method 1

The liquid nutritional composition also includes from 1,500 ppm to 3,000 ppm of a stabilizer component. In such an embodiment, the stabilizer component may include at least one of microcrystalline cellulose, carboxymethylcellulose, gellan gum, and carrageenan.

Methodology Applied
Scientific EffectSteric stabilization:

Implementation Method 2

The liquid nutritional composition has a pH of 6.4 to 7.5... maintaining stability and organoleptic properties, enabling the use of desirable flavors while avoiding issues like gelation and phase separation.

Methodology Applied
Scientific EffectElectrostatic repulsion: Ion Repulsion/Attraction

Implementation Method 3

The protein consists of a whey protein hydrolysate and an intact whey protein... the whey protein hydrolysate may have a degree of hydrolysis of 5% to 30%.

Methodology Applied
Scientific EffectProtein hydrolysis: Hydrolysis

Data Source

PatentUS11540548B2Whey protein based liquid nutritional composition
Publication Date: 2023.01.03 ABBOTT LAB INC

AI summary

Whey protein based liquid nutritional compositions are provided. The liquid nutritional compositions include at least 7% by weight protein and all of the protein is provided by a whey protein hydrolysate and an intact whey protein. The liquid nutritional compositions have a neutral pH, a low viscosity, and are shelf stable.