Triazole compounds that modulate HSP90 activity
Novel triazole compounds targeting Hsp90 activity address the limitations of current cancer treatments by disrupting multiple oncogenic pathways, offering a more effective approach to cancer treatment by inhibiting Hsp90 and its client proteins.
CA2653332A1Inactive Publication Date: 2007-12-06SYNTA PHARMA CORP
0 Cites 0 Cited by
Patent Information
- Application Number
- CA2653332
- Authority / Receiving Office
- CA · CA
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2006-05-25
- Filing Date
- 2007-05-25
- Publication Date
- 2007-12-06
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Technical Problem
Current cancer treatments often target only one molecular pathway, leading to multidrug resistance and ineffective tumor regression, as most chemotherapeutic agents fail to address the complex network of signaling pathways involved in cancer progression.
Method used
Development of novel triazole compounds that inhibit Hsp90 activity, facilitating the degradation of client proteins involved in signal transduction, thereby short-circuiting multiple pathways contributing to cancer progression.
Benefits of technology
Inhibiting Hsp90 activity with these compounds can lead to simultaneous disruption of several oncogenic pathways, potentially resulting in more effective tumor regression and reduced development of multidrug-resistant tumors.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
Need to check novelty before this filing date? Find Prior Art