A compound which is a casein kinase inhibitor

By providing casein kinase inhibitor compounds with specific structures, the problem of insufficient casein kinase inhibitors in the prior art has been solved, and effective treatment of circadian rhythm disorders has been achieved.

CN116888126BActive Publication Date: 2026-03-17GRITSCI BIOPHARM CO LTD
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Patent Information

Application Number
CN202180083438.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Priority Date
2020-12-15
Filing Date
2021-12-14
Publication Date
2026-03-17
Estimated Expiration
2041-12-14

AI Technical Summary

Technical Problem

The lack of effective casein kinase inhibitors in current technologies makes it difficult to effectively treat diseases related to circadian rhythm disorders such as depression, seasonal affective disorder, and metabolic disorders.

Method used

A series of compounds with specific structures are provided as effective inhibitors of casein kinase, including pharmaceutically acceptable salts, prodrugs, or solvates thereof, for inhibiting the activity of casein kinase.

Benefits of technology

These compounds can effectively inhibit casein kinase, preventing and treating diseases associated with circadian rhythm disorders such as mood disorders, sleep disorders, and circadian rhythm disorders, especially depression and bipolar disorder.

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Abstract

This disclosure provides casein kinase inhibitors or pharmaceutically acceptable salts thereof. Corresponding compositions, treatment methods, and intermediates are also provided.
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