A microfluidic chip with a flow channel switching valve
By designing a microfluidic chip for the runner switching valve, the automatic laying of magnetic beads and simplified operation are achieved, solving the problems of complex magnetic bead detection process and waste of reagents in the prior art, improving detection efficiency and reducing costs.
Patent Information
- Application Number
- CN202311054071.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-08-21
- Publication Date
- 2025-08-19
- Estimated Expiration
- 2043-08-21
AI Technical Summary
Due to the low pore rate of existing microfluidic chips, they need to be washed with oil layers or other reagents. The steps are cumbersome and waste reagents. The process of generating magnetic bead sample antibody mixed microspheres when detecting antigen concentration is time-consuming and complicated and easy to cause aerosol contamination.
A microfluidic chip with a flow channel switching valve is designed, including a cleaning liquid flow channel, a buffer flow channel, a waste liquid flow channel, a first mixing flow channel and a second mixing flow channel. The flow channel switching valve has four working states. Through the state switching of the flow channel switching valve, the magnetic beads are automatically laid on the focal plane, avoiding the overlap of mixed microballoons up and down, and the flow channel switching valve is used as the incubation area and cleaning position to simplify the operation steps.
It improves the efficiency of antigen concentration detection, simplifies operation steps, reduces the production cost of microfluidic chips, avoids aerosol contamination, and saves the use of reagents.