Treatment of Coronavirus Infection
By using ABC294640 to inhibit the activity of the host cytokine sphingosine kinase-2 (SK2), the problem of difficulty in effectively treating COVID-19 in the prior art is solved, and the effect of reducing viral load and reducing symptoms is achieved.
CN117695284BActive Publication Date: 2025-06-17REDHILL BIOPHARMA LTD
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Patent Information
- Application Number
- CN202311591091.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Priority Date
- 2020-12-15
- Filing Date
- 2021-03-08
- Publication Date
- 2025-06-17
- Estimated Expiration
- 2041-03-08
AI Technical Summary
Technical Problem
The prior art is difficult to effectively treat the coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus.
Method used
ABC294640 is used as a free base or a salt thereof, administered by oral or other routes for the treatment of COVID-19. ABC294640 has the activity of inhibiting the host cytokine sphingosine kinase-2 (SK2), thereby regulating viral replication.
Benefits of technology
Effectively reduce viral load, relieve symptoms, and provide a new treatment for COVID-19.
✦ Generated by Eureka AI based on patent content.
Abstract
The present disclosure generally relates to the fields of virology, infectious diseases, and medicine, and describes compounds, compositions, methods, and kits for treating CoV-mediated diseases such as those caused by SARS-CoV-2, SAR8, or MERS. More specifically, the present disclosure relates to effective inhibitors of coronaviruses, which can treat coronaviruses, including the 2019 novel coronavirus. In one embodiment, the present disclosure provides a new use of WX-671 as an effective inhibitor of coronaviruses and its application in the preparation of a medicament for treating human coronavirus infection. In one embodiment, the present disclosure provides a new use of ABC294640 as an effective inhibitor of coronaviruses and its application in the preparation of a medicament for treating human coronavirus infection.
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