A novel anti-phage system and its application

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By constructing an NBASS system composed of ADA, HAM1, and SIR2 proteins, the problem of difficulty in detecting dITP and a single anti-phage system in the prior art cannot fully defend against multiple phages, and the rapid and sensitive effects of broad-spectrum defense against phages and dITP detection are achieved.

CN118726323BActive Publication Date: 2025-04-11HUAZHONG AGRI UNIV

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Patent Information

Application Number: CN202411096444.X
Authority / Receiving Office: CN · China
Patent Type: Patents(China)
Current Assignee / Owner
Filing Date: 2024-08-12
Publication Date: 2025-04-11
Estimated Expiration: 2044-08-12

Application Information

Patent Timeline

12 Aug 2024

Application

CN202411096444.X

11 Apr 2025

Publication

CN118726323B

IPC: C12N9/78; C12N9/14; C12N15/70; C12N15/55; C12N1/21; A61K38/50; A61K38/46; A61P31/12; G01N21/64; C12R1/19

CPC: C12N9/78; C12N9/14; C12N15/70; A61P31/12; G01N21/6428; C12Y305/04004; C12N2800/101; C12R2001/19

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Application Domain

Bacteria Peptide/protein ingredients

Technology Topics

Biotechnology Disease

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AI Technical Summary

Technical Problem

The prior art is difficult to detect the accumulation of deoxygenated hypoxanthine nucleoside triphosphate (dITP) quickly and sensitively, and a single anti-phage system cannot fully defend against a wide variety of phages.

Method used

A composition is developed consisting of three proteins: ADA, HAM1, and SIR2. Using the specific domain functions of these proteins, an NBASS system was constructed for anti-phage defense, and incubating the HS complex with NAD+ with fluorescent groups to detect the presence of dITP in the sample.

Benefits of technology

It realizes broad-spectrum and efficient defense of a variety of bacteriophages, can quickly and sensitively detect dITP, and supports scientific research and disease analysis related to nucleotide metabolism.

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Abstract

The present invention discloses a novel anti-phage system NBASS and its application, belonging to the fields of biotechnology and genetic engineering. NBASS is composed of three proteins, which can synthesize deoxyinosine triphosphate (dITP) after sensing the deoxynucleoside monophosphate kinase of the phage, activate the effector protein, and thus exert the anti-phage function. Based on this system, the present invention has developed a broad-spectrum anti-phage tool, which can be used for phage prevention and control in the process of microbial fermentation; the present invention has also developed a dITP detection tool, which can be used for scientific research and disease analysis related to nucleotide metabolism.

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